Yasthimadhu: Difference between revisions
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Yashtimadhu (Glycyrrhiza glabra L., Liquorice, Fabaceae) is a widely recognized medicinal herb in [[Ayurveda|Ayurvedic medicine]] and modern phytotherapy, valued for its gastroprotective, anti-inflammatory, antiviral, and hepatoprotective properties. Its bioactivity is primarily mediated by triterpenoid saponins, notably | Yashtimadhu (Glycyrrhiza glabra L., Liquorice, Fabaceae) is a widely recognized medicinal herb in [[Ayurveda|Ayurvedic medicine]] and modern phytotherapy, valued for its gastroprotective, anti-inflammatory, antiviral, and hepatoprotective properties. Its bioactivity is primarily mediated by triterpenoid saponins, notably glycyrrhizin, and prenylated flavonoids like glabridin. | ||
== Botanical & Phytochemical Profile == | == Botanical & Phytochemical Profile == | ||
* '''Scientific Name:''' '' | * '''Scientific Name:''' ''Glycyrrhiza glabra'' L. (Family: Fabaceae) | ||
* '''Ayurvedic Name:''' ''Yashtimadhu'', ''Madhuka'' | * '''Ayurvedic Name:''' ''Yashtimadhu'', ''Madhuka'' | ||
* '''Triterpenoid Saponins:''' | * '''Triterpenoid Saponins:''' Glycyrrhizin (glycyrrhizic acid), 18β-glycyrrhetinic acid | ||
* '''Flavonoids & Isoflavonoids:''' | * [[File:Yashtimadhu.jpg|thumb|'''Yashtimadhu (''Glycyrrhiza glabra'')''']]'''Flavonoids & Isoflavonoids:''' Glabridin, liquiritin, isoliquiritigenin, licochalcone A, glabrene | ||
== Synonyms in Charak Samhita== | == Synonyms in Charak Samhita== | ||
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| 15 || Cha.Sa. Sutra sthana 5/63 || Anu taila dravya | | 15 || Cha.Sa. Sutra sthana 5/63 || Anu taila dravya | ||
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| 5 || Actions ([[karma]]) || Pacify [[vata]] and [[pitta]] | | 5 || Actions ([[karma]]) || Pacify [[vata]] and [[pitta]] | ||
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* '''Mucosal Defense:''' Enhances gastric mucosal secretion, increases regional blood flow, and suppresses lipid peroxidation, accelerating the healing of peptic ulcers.<ref name="Asl2008" /> | * '''Mucosal Defense:''' Enhances gastric mucosal secretion, increases regional blood flow, and suppresses lipid peroxidation, accelerating the healing of peptic ulcers.<ref name="Asl2008" /> | ||
* '''Enzyme Regulation:''' Inhibits 11β-hydroxysteroid dehydrogenase type 1, preserving protective mucosal prostaglandin levels (PGE<sub>2</sub>).<ref name="Kwon2020" /> | * '''Enzyme Regulation:''' Inhibits 11β-hydroxysteroid dehydrogenase type 1, preserving protective mucosal prostaglandin levels (PGE<sub>2</sub>).<ref name="Kwon2020" /> | ||
* '''Anti-''H. pylori'':''' Deglycyrrhizinated licorice (DGL) preparations inhibit '' | * '''Anti-''H. pylori'':''' Deglycyrrhizinated licorice (DGL) preparations inhibit ''Helicobacter pylori'' mucosal adherence without causing mineralocorticoid-related side effects.<ref name="Kwon2020" /> | ||
=== Anti-Inflammatory & Immunomodulatory Effects === | === Anti-Inflammatory & Immunomodulatory Effects === | ||
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! Bioactive Constituent !! Phytochemical Class !! Molecular Targets !! Primary Therapeutic Efficacy | ! Bioactive Constituent !! Phytochemical Class !! Molecular Targets !! Primary Therapeutic Efficacy | ||
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| ''' | | '''Glycyrrhizin''' || Triterpenoid Saponin || M<sup>pro</sup> protease, HMGB1, 11β-HSD || Gastroprotective, Antiviral, Anti-ulcer | ||
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| ''' | | '''Glabridin''' || Isoflavane || COX-2, iNOS, ROS, PPAR-γ || Antioxidant, Hepatoprotective, Anti-atherogenic | ||
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| ''' | | '''Isoliquiritigenin''' || Chalcone || NF-κB, Nrf2 pathway || Spasmolytic, Immunomodulatory, Anti-tumor | ||
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| ''' | | '''Liquiritin''' || Flavanone || TRPV1 / Capsaicin receptors || Antitussive, Expectorant, Neuroprotective | ||
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[[Category:Database of herbs and minerals|Herbs]] | [[index.php?title=Category:Database of herbs and minerals|Herbs]] | ||