Talk:Guduchi: Difference between revisions
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== Safety and hepatotoxicity == | == Safety and hepatotoxicity == | ||
In recent years, several case reports and reviews have described herb‑induced liver injury associated with Guduchi or ''Tinospora''‑containing products.<ref name="LiverTox"/ | In recent years, several case reports and reviews have described herb‑induced liver injury associated with Guduchi or ''Tinospora''‑containing products.<ref name="LiverTox"/>,<ref name="PMC2021LiverInjury">Björnsson ES, Navarro VJ, Chalasani N. Liver Injury Following Tinospora Cordifolia Consumption: Drug-Induced AIH, or de novo AIH? J Clin Exp Hepatol. 2022 Jan-Feb;12(1):6-9. doi: 10.1016/j.jceh.2021.11.014. Epub 2021 Nov 29. PMID: 35068778; PMCID: PMC8766689.</ref> | ||
The NIH LiverTox resource notes that Guduchi‑associated liver injury can range from mild elevation of liver enzymes to clinically significant hepatitis and, rarely, acute liver failure, with some cases showing autoimmune‑like features.<ref name="LiverTox"/> Many cases occur in patients with pre‑existing liver disease or autoimmune predisposition and may be idiosyncratic or immune‑mediated.<ref name="LiverTox | The NIH LiverTox resource notes that Guduchi‑associated liver injury can range from mild elevation of liver enzymes to clinically significant hepatitis and, rarely, acute liver failure, with some cases showing autoimmune‑like features.<ref name="LiverTox"/> Many cases occur in patients with pre‑existing liver disease or autoimmune predisposition and may be idiosyncratic or immune‑mediated.<ref name="LiverTox"/> | ||
The AYUSH technical dossier highlights that many published liver injury reports lack detailed baseline documentation and may mix different species and preparations, underscoring the need for careful botanical identification, product quality control, and medical supervision, especially in patients with pre‑existing liver conditions.<ref name="AYUSHDossier"/> | The AYUSH technical dossier highlights that many published liver injury reports lack detailed baseline documentation and may mix different species and preparations, underscoring the need for careful botanical identification, product quality control, and medical supervision, especially in patients with pre‑existing liver conditions.<ref name="AYUSHDossier"/> | ||