Shankhapushpi: Difference between revisions
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Evolvulus alsinoides L. or Convolvulus pluricaulis | [[wikipedia:Evolvulus_alsinoides|Evolvulus alsinoides L.]] or [[wikipedia:Convolvulus_prostratus|Convolvulus pluricaulis]] | ||
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'''''Evolvulus alsinoides''''' (L.) L., commonly known as '''Dwarf Morning Glory''', is a prominent perennial herb revered across traditional Asian medicine systems—particularly Ayurveda and Unani—for its neuroprotective and cognitive-enhancing capabilities.Singh, A. (2021). A systematic review of the phytochemical profile and medicinal significance of ''Evolvulus alsinoides''. ''Journal of Medicinal Plants and Studies'', 9(3), 45-52. | '''''Evolvulus alsinoides''''' (L.) L., commonly known as '''Dwarf Morning Glory''', is a prominent perennial herb revered across traditional Asian medicine systems—particularly Ayurveda and Unani—for its neuroprotective and cognitive-enhancing capabilities.<ref>Singh, A. (2021). A systematic review of the phytochemical profile and medicinal significance of ''Evolvulus alsinoides''. ''Journal of Medicinal Plants and Studies'', 9(3), 45-52.</ref> | ||
Within Ayurvedic pharmacology, the vernacular name '''''Shankhapushpi''''' is applied to a select group of plants recognized as premier ''Medhya Rasayanas'' (intellect-rejuvenating tonics). While ''Convolvulus pluricaulis'' Choisy is widely used under this moniker, ''Evolvulus alsinoides'' serves as its primary counterpart or preferred substitute in many geographical regions, exhibiting an overlapping and often superior pharmacological profile in preclinical evaluations. | Within Ayurvedic pharmacology, the vernacular name '''''Shankhapushpi''''' is applied to a select group of plants recognized as premier ''Medhya Rasayanas'' (intellect-rejuvenating tonics). While ''Convolvulus pluricaulis'' Choisy is widely used under this moniker, ''Evolvulus alsinoides'' serves as its primary counterpart or preferred substitute in many geographical regions, exhibiting an overlapping and often superior pharmacological profile in preclinical evaluations. | ||
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* '''Family:''' Convolvulaceae | * '''Family:''' Convolvulaceae | ||
* '''Genus:''' ''Evolvulus'' | * '''Genus:''' ''Evolvulus'' | ||
* '''Species:''' ''E. alsinoides'' (L.) | * '''Species:''' ''E. alsinoides'' (L.) | ||
[[File:Shankhapushpi labels.jpg|thumb|Two varieties of Shankhapushpi]] | |||
[[File:Shankhapushpi.jpg|thumb|Shankhapushpi (''Convolvulus pluricaulis)'']] | |||
=== Morphological Synopsis === | === Morphological Synopsis === | ||
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==Synonyms in Bhavaprakasha Nighantu== | ==Synonyms in Bhavaprakasha Nighantu== | ||
Shankhpushpi, Shankhahva, Mangalyakusuma<ref>Prof. K.C.Chunekar, Bhavprakasha Nighantu, Reprint.2015, Chaukhambha vishvabharti, Guduchyadi Varga, verse no. 269, p.439.</ref>, Vishnukranta | Shankhpushpi, Shankhahva, Mangalyakusuma<ref>Prof. K.C.Chunekar, Bhavprakasha Nighantu, Reprint.2015, Chaukhambha vishvabharti, Guduchyadi Varga, verse no. 269, p.439.</ref>, Vishnukranta | ||
{| class="wikitable" | {| class="wikitable" | ||
== Ayurvedic pharmacological properties == | == Ayurvedic pharmacological properties == | ||
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==Current researches == | ==Current researches == | ||
== Phytochemical Landscape == | == Phytochemical Landscape == | ||
The multi-targeted therapeutic efficacy of ''E. alsinoides'' is attributed to its complex matrix of secondary metabolites.Kumar, S. (2013). Secondary metabolite credentials of ''Evolvulus alsinoides'' by high performance thin layer chromatography (HPTLC). ''Journal of Pharmacognosy and Phytochemistry'', 2(1), 112-118. Standardized extractions (specifically using ethanolic and methanolic media) have isolated several key classes of bioactive constituents: | The multi-targeted therapeutic efficacy of ''E. alsinoides'' is attributed to its complex matrix of secondary metabolites.<ref>Kumar, S. (2013). Secondary metabolite credentials of ''Evolvulus alsinoides'' by high performance thin layer chromatography (HPTLC). ''Journal of Pharmacognosy and Phytochemistry'', 2(1), 112-118.</ref> Standardized extractions (specifically using ethanolic and methanolic media) have isolated several key classes of bioactive constituents: | ||
* '''Alkaloids:''' Shankhapushpine, evolvine, and betaine. Betaine, in particular, has been correlated with wound-healing and neuro-regulatory functions. | * '''Alkaloids:''' Shankhapushpine, evolvine, and betaine. Betaine, in particular, has been correlated with wound-healing and neuro-regulatory functions. | ||
* '''Coumarins:''' Significant quantities of scopoletin, scopolin, and umbelliferone, which mediate substantial free-radical scavenging and anti-inflammatory properties. | * '''Coumarins:''' Significant quantities of scopoletin, scopolin, and umbelliferone, which mediate substantial free-radical scavenging and anti-inflammatory properties. | ||
* '''Phenolic Glycosides & Flavonoids:''' Resin glycosides known as '''Evolvosides''' (specifically Evolvosides B, C, D, and E) represent major unique drivers of its adaptogenic effects.Siripurapu, K. B., et al. (2005). Adaptogenic and anti-amnesic properties of ''Evolvulus alsinoides'' in rodents. ''Pharmacology Biochemistry and Behavior'', 81(3), 424-432. Additionally, kaempferol and quercetin derivatives are present, reinforcing its systemic antioxidant potential. | * '''Phenolic Glycosides & Flavonoids:''' Resin glycosides known as '''Evolvosides''' (specifically Evolvosides B, C, D, and E) represent major unique drivers of its adaptogenic effects.<ref>Siripurapu, K. B., et al. (2005). Adaptogenic and anti-amnesic properties of ''Evolvulus alsinoides'' in rodents. ''Pharmacology Biochemistry and Behavior'', 81(3), 424-432. </ref>Additionally, kaempferol and quercetin derivatives are present, reinforcing its systemic antioxidant potential. | ||
* '''Sterols and Triterpenes:''' β-sitosterol, squalene, and phytol. | * '''Sterols and Triterpenes:''' β-sitosterol, squalene, and phytol. | ||
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* '''Adaptogenic Efficacy:''' In acute and chronic unpredictable stress paradigms in rats, ''E. alsinoides'' extracts (200 mg/kg p.o.) successfully attenuated stress-induced physiological imbalances. It normalized stress-induced hyperglycemia, plasma corticosterone elevations, creatine kinase spikes, and adrenal hypertrophy. The performance was analogous to the benchmark adaptogen ''Panax ginseng''. Isolates such as '''Evolvosides C–E''' have been identified as primary drivers of this HPA-axis (hypothalamic-pituitary-adrenal) stabilization. | * '''Adaptogenic Efficacy:''' In acute and chronic unpredictable stress paradigms in rats, ''E. alsinoides'' extracts (200 mg/kg p.o.) successfully attenuated stress-induced physiological imbalances. It normalized stress-induced hyperglycemia, plasma corticosterone elevations, creatine kinase spikes, and adrenal hypertrophy. The performance was analogous to the benchmark adaptogen ''Panax ginseng''. Isolates such as '''Evolvosides C–E''' have been identified as primary drivers of this HPA-axis (hypothalamic-pituitary-adrenal) stabilization. | ||
* '''Anxiolytic Activity:''' In the elevated plus maze (EPM) and open field test (OFT) paradigms, the ethyl acetate fractions of ''E. alsinoides'' at 100 mg/kg p.o. induced potent anxiolytic actions.Bhowmik, D., et al. (2009). Anxiolytic activity of ''Evolvulus alsinoides'' and ''Convolvulus pluricaulis'' in rodents. ''Pharmaceutical Biology'', 47(11), 1092-1097. The subjects showed a highly significant increase in both the time spent and the number of entries into the open arms of the maze, demonstrating a marked reduction in baseline anxiety that points directly toward interaction with central GABAergic neurotransmission pathways. | * '''Anxiolytic Activity:''' In the elevated plus maze (EPM) and open field test (OFT) paradigms, the ethyl acetate fractions of ''E. alsinoides'' at 100 mg/kg p.o. induced potent anxiolytic actions.<ref>Bhowmik, D., et al. (2009). Anxiolytic activity of ''Evolvulus alsinoides'' and ''Convolvulus pluricaulis'' in rodents. ''Pharmaceutical Biology'', 47(11), 1092-1097.</ref> The subjects showed a highly significant increase in both the time spent and the number of entries into the open arms of the maze, demonstrating a marked reduction in baseline anxiety that points directly toward interaction with central GABAergic neurotransmission pathways. | ||
=== Antioxidant and Neuroprotective Profile === | === Antioxidant and Neuroprotective Profile === | ||
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Neurodegenerative pathobiology is heavily tethered to chronic oxidative stress and neuroinflammation. | Neurodegenerative pathobiology is heavily tethered to chronic oxidative stress and neuroinflammation. | ||
* ''E. alsinoides'' displays robust free radical scavenging capabilities.Auddy, B., et al. (2003). Screening of antioxidant activity and antioxidant compounds of some edible plants. ''Journal of Ethnopharmacology'', 84(1), 131-138. Phenolic and coumarin components (like scopoletin) exhibit significant concentration-dependent inhibition of lipid peroxidation and strong DPPH radical scavenging activity.Ganpat, M., et al. (2007). Evaluation of natural substances from ''Evolvulus alsinoides'' L. with the purpose of determining their antioxidant potency. ''Journal of Enzyme Inhibition and Medicinal Chemistry'', 22(5), 595-601. | * ''E. alsinoides'' displays robust free radical scavenging capabilities.<ref>Auddy, B., et al. (2003). Screening of antioxidant activity and antioxidant compounds of some edible plants. ''Journal of Ethnopharmacology'', 84(1), 131-138.</ref> Phenolic and coumarin components (like scopoletin) exhibit significant concentration-dependent inhibition of lipid peroxidation and strong DPPH radical scavenging activity.<ref>Ganpat, M., et al. (2007). Evaluation of natural substances from ''Evolvulus alsinoides'' L. with the purpose of determining their antioxidant potency. ''Journal of Enzyme Inhibition and Medicinal Chemistry'', 22(5), 595-601.</ref> | ||
* By scavenging reactive oxygen species (ROS) and upgrading endogenous enzymatic antioxidants (superoxide dismutase, catalase, and glutathione), the herb shields cortical and hippocampal neurons from cell death, indicating broad-spectrum utility in mitigating progress in conditions like dementia and Parkinson’s disease. | * By scavenging reactive oxygen species (ROS) and upgrading endogenous enzymatic antioxidants (superoxide dismutase, catalase, and glutathione), the herb shields cortical and hippocampal neurons from cell death, indicating broad-spectrum utility in mitigating progress in conditions like dementia and Parkinson’s disease. | ||
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{{reflist}} | {{reflist}} | ||
==External links== | |||
[https://cb.imsc.res.in/imppat/basicsearch/phytochemical IMPPAT database] | |||
[[Category:Database of herbs and minerals Herbs]] | [[Category:Database of herbs and minerals Herbs]] | ||