Talk:Atibala: Difference between revisions
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=== 1. Anti-inflammatory and Analgesic Activity === | === 1. Anti-inflammatory and Analgesic Activity === | ||
* '''Traditional Use:''' Indicated in ''Vatarakta'' (gout) and inflammatory joint discomforts.<ref name="API" /> | * '''Traditional Use:''' Indicated in ''Vatarakta'' (gout) and inflammatory joint discomforts.<ref name="API" /> | ||
* '''Scientific Evidence:''' | * '''Scientific Evidence:''' The analgesic effect of petroleum ether, methanol, ethanol and aqueous extracts of ''A. indicum'' root was evaluated in mice using the acetic acid-induced writhing, tail flick and tail immersion methods.<ref name="Goyal2009" /> The analgesic and anti-inflammatory activities of ''A. indicum'' whole-plant extracts have also been evaluated experimentally.<ref name="Saraswathi2011" /> Anti-inflammatory and analgesic activities are reported across the genus ''Abutilon''.<ref name="Gomaa2018" /> | ||
=== 2. Hepatoprotective Activity === | === 2. Hepatoprotective Activity === | ||
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=== 4. Hypoglycemic and Antidiabetic Effects === | === 4. Hypoglycemic and Antidiabetic Effects === | ||
* '''Traditional Use:''' Traditionally managed under ''Meha'' conditions.<ref name="API" /> | * '''Traditional Use:''' Traditionally managed under ''Meha'' conditions.<ref name="API" /> | ||
* '''Scientific Evidence:''' | * '''Scientific Evidence:''' Alcohol and water extracts of ''A. indicum'' leaves (400 mg/kg, orally) produced a significant hypoglycemic effect in normal rats 4 hours after administration (23.10% and 26.95% respectively).<ref name="Seetharam2002" /> The aqueous extract reduced plasma glucose in diabetic rats during an oral glucose tolerance test (0.5 and 1 g/kg), by inhibiting glucose absorption and stimulating insulin secretion.<ref name="Krisanapun2009" /> In cell studies, the butanol fraction bound to PPARγ and promoted adipocyte differentiation, and the crude extract activated the GLUT1 promoter.<ref name="Krisanapun2011" /> | ||
== Summary of Therapeutic Profile == | == Summary of Therapeutic Profile == | ||
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|- | |- | ||
| '''Inflammation & Gout (''Vatarakta'')''' | | '''Inflammation & Gout (''Vatarakta'')''' | ||
| | | Analgesic, anti-inflammatory<ref name="Goyal2009" /><ref name="Saraswathi2011" /> | ||
|- | |- | ||
| '''Liver Health''' | | '''Liver Health''' | ||
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<ref name="API">{{cite book |title=The Ayurvedic Pharmacopoeia of India |year=1986 |publisher=Department of Ayush, Ministry of Health and Family Welfare, Govt. of India |location=New Delhi |edition=Part I |volume=I |pages=13}}</ref> | <ref name="API">{{cite book |title=The Ayurvedic Pharmacopoeia of India |year=1986 |publisher=Department of Ayush, Ministry of Health and Family Welfare, Govt. of India |location=New Delhi |edition=Part I |volume=I |pages=13}}</ref> | ||
<ref name="Kaushik2009">{{cite journal |last1=Kaushik |first1=P. |last2=Kaushik |first2=D. |last3=Khokra |first3=S. |last4=Chaudhary |first4=B. |year=2009 |title=Abutilon indicum (Atibala): ethno-botany, phytochemistry and pharmacology – a review |journal=International Journal of Pharmaceutical and Clinical Research |volume=1 |issue=1 |pages=4–9 |url=https://www.lavierebelle.org/IMG/pdf/abutilon_indicum_atibala_ethno-botany_phytochemistry_and_pharmacology-_a_review.pdf}}</ref> | <ref name="Kaushik2009">{{cite journal |last1=Kaushik |first1=P. |last2=Kaushik |first2=D. |last3=Khokra |first3=S. |last4=Chaudhary |first4=B. |year=2009 |title=Abutilon indicum (Atibala): ethno-botany, phytochemistry and pharmacology – a review |journal=International Journal of Pharmaceutical and Clinical Research |volume=1 |issue=1 |pages=4–9 |url=https://www.lavierebelle.org/IMG/pdf/abutilon_indicum_atibala_ethno-botany_phytochemistry_and_pharmacology-_a_review.pdf}}</ref> | ||
<ref name="Gomaa2018">{{cite journal |last1=Gomaa |first1=A. A.-R. |last2=Samy |first2=M. N. | | <ref name="Gomaa2018">{{cite journal |last1=Gomaa |first1=A. A.-R. |last2=Samy |first2=M. N. |display-authors=etal |year=2018 |title=Phytochemistry and pharmacological activities of genus Abutilon: a review (1972–2015) |journal=Journal of Advanced Biomedical and Pharmaceutical Sciences |volume=1 |issue=2 |pages=56–74 |doi=10.21608/jabps.2018.3333.1000 |url=https://journals.ekb.eg/article_14982.html}}</ref> | ||
<ref name="Seetharam2002">{{cite journal |last1=Seetharam |first1=Y. N. |last2=Chalageri |first2=G. |last3=Setty |first3=S. R. |last4=Bheemachar |year=2002 |title=Hypoglycemic activity of Abutilon indicum leaf extracts in rats |journal=Fitoterapia |volume=73 |issue=2 |pages=156–159 |url=https:// | <ref name="Goyal2009">{{cite journal |last1=Goyal |first1=N. |last2=Singh |first2=S. |last3=Sharma |first3=S. K. |year=2009 |title=Analgesic effects of various extracts of the root of Abutilon indicum Linn |journal=Journal of Pharmacy and Bioallied Sciences |volume=1 |issue=1 |pages=43–46 |doi=10.4103/0975-7406.62686 |url=https://doi.org/10.4103/0975-7406.62686}}</ref> | ||
<ref name="Krisanapun2009">{{cite journal |last1=Krisanapun |first1=C. |last2=Peungvicha |first2=P. |last3=Temsiririrkkul |first3=R. |last4=Wongkrajang |first4=Y. |year=2009 |title=Aqueous extract of Abutilon indicum Sweet inhibits glucose absorption and stimulates insulin secretion in rodents |journal=Nutrition Research |volume=29 |issue=8 |pages=579–587 |url=https:// | <ref name="Saraswathi2011">{{cite journal |last1=Saraswathi |first1=R. |last2=Upadhyay |first2=L. |last3=Venkatakrishnan |first3=R. |last4=Meera |first4=R. |last5=Devi |first5=P. |year=2011 |title=Phytochemical investigation, analgesic and anti inflammatory activity of Abutilon indicum Linn |journal=International Journal of Pharmacy and Pharmaceutical Sciences |volume=3 |issue=Suppl 2 |pages=154–156 |url=https://innovareacademics.in/journal/ijpps/Vol3Suppl2/1147.pdf}}</ref> | ||
<ref name="Krisanapun2011">{{cite journal |last1=Krisanapun |first1=C. |last2=Lee |first2=S.-H. |last3=Peungvicha |first3=P. |last4=Temsiririrkkul |first4=R. |last5=Baek |first5=S. J. |year=2011 |title=Antidiabetic activities of Abutilon indicum (L.) Sweet are mediated by enhancement of adipocyte differentiation and activation of the GLUT1 promoter |journal=Evidence-Based Complementary and Alternative Medicine |volume=2011 |url=https://pmc.ncbi.nlm.nih.gov/articles/PMC3094712}}</ref> | <ref name="Seetharam2002">{{cite journal |last1=Seetharam |first1=Y. N. |last2=Chalageri |first2=G. |last3=Setty |first3=S. R. |last4=Bheemachar |year=2002 |title=Hypoglycemic activity of Abutilon indicum leaf extracts in rats |journal=Fitoterapia |volume=73 |issue=2 |pages=156–159 |doi=10.1016/S0367-326X(02)00015-1 |pmid=11978431 |url=https://pubmed.ncbi.nlm.nih.gov/11978431/}}</ref> | ||
<ref name="Krisanapun2009">{{cite journal |last1=Krisanapun |first1=C. |last2=Peungvicha |first2=P. |last3=Temsiririrkkul |first3=R. |last4=Wongkrajang |first4=Y. |year=2009 |title=Aqueous extract of Abutilon indicum Sweet inhibits glucose absorption and stimulates insulin secretion in rodents |journal=Nutrition Research |volume=29 |issue=8 |pages=579–587 |doi=10.1016/j.nutres.2009.07.006 |pmid=19761892 |url=https://pubmed.ncbi.nlm.nih.gov/19761892/}}</ref> | |||
<ref name="Krisanapun2011">{{cite journal |last1=Krisanapun |first1=C. |last2=Lee |first2=S.-H. |last3=Peungvicha |first3=P. |last4=Temsiririrkkul |first4=R. |last5=Baek |first5=S. J. |year=2011 |title=Antidiabetic activities of Abutilon indicum (L.) Sweet are mediated by enhancement of adipocyte differentiation and activation of the GLUT1 promoter |journal=Evidence-Based Complementary and Alternative Medicine |volume=2011 |doi=10.1093/ecam/neq004 |url=https://pmc.ncbi.nlm.nih.gov/articles/PMC3094712}}</ref> | |||
}} | }} | ||