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<noinclude>
{{#seo:
{{#seo:
|title=Charak Samhita - Herb Database
|title=Charak Samhita
|titlemode=append
|titlemode=append
|keywords=Dipyaka, Carum copticum, Trachyspermum ammi, Ajowan, Ajwain, Charak Samhita, Dravyaguna, Ayurvedic pharmacopoeia
|keywords= *Dipyaka, Carum copticum Benth. & Hook, Ajowan* Therapeutic use, herbs, researches on dravya, Charak Samhita, Dravyaguna, carakasamhitaonline, carakasamhita, caraka samhita, Ayurveda, Charak Samhita English translation, ancient Ayurveda text, Indian system of medicine, Ayurveda, Charak, Charaka Samhita, agnivesha, atreya, gopal basisht, yogesh deole, charak samhita wikipedia edition, charak samhita new edition, charaka samhita new edition, carak samhita new edition, caraka samhita new edition, research on charak samhita, text book charak samhita, fundamental principles of ayurveda, basic concepts of ayurveda,
|description=Monograph on Dipyaka (Carum copticum Benth. & Hook): comprehensive botanical profile, classical Ayurvedic pharmacodynamics, therapeutic efficacy, and modern scientific research.
|description= Dipyaka (Trachyspermum ammi (L.) Sprague / Carum copticum) is traditionally classified as a deepana (digestive stimulant), pachana, and anulomaka herb, widely utilized in Ayurveda for managing gastrointestinal disorders, abdominal colic, indigestion, and respiratory ailments.
|image=http://www.carakasamhitaonline.com/resources/assets/ogimgs.jpg
|image=http://www.carakasamhitaonline.com/resources/assets/ogimgs.jpg
|image_alt=Dipyaka - Carum copticum
|image_alt=charak samhita
|type=article
|type=article
}}
}}
</noinclude>


{{Infobox
{{Infobox
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}}
}}


'''[https://en.wikipedia.org/wiki/Trachyspermum_ammi Carum copticum Benth. & Hook.]''', commonly known as '''Dipyaka''' or '''Ajowan''', is an annual herbaceous plant widely cultivated for its aromatic fruits. In [[Ayurveda]], it is highly valued as a carminative, digestive stimulant, and Kapha-Vata pacifying medicine.<ref name="API">Anonymous. The Ayurvedic Pharmacopoeia of India. Department of Ayush, Ministry of Health and Family Welfare, Govt. of India, New Delhi, Part I. 1986; Volume I:02</ref>
'''[https://en.wikipedia.org/wiki/Trachyspermum_ammi Carum copticum Benth. & Hook.]''', commonly known as '''Dipyaka''' or '''Ajowan''', is an annual herbaceous plant widely cultivated for its aromatic fruits. In [[Ayurveda]], it is highly valued as a carminative, digestive stimulant, and Kapha-Vata pacifying medicine.<ref name="API" /> ''Trachyspermum ammi'' (L.) Sprague is regarded as a synonym of ''Carum copticum''.<ref name="Boskabady2014" />


== English Name ==
== English Name ==
Line 52: Line 50:
* ''Brahmakusha''
* ''Brahmakusha''
* ''Kaaravi''
* ''Kaaravi''
* ''Lochamastaka''<ref name="Bhavaprakash">Shri Bhavamishra, Bhavaprakash Nighantu, Haritakyadi Varga, verse no.- 77, Edited by Padmashree Prof. Krushnachandra Chunekar, Reprint Edition, Chaukhambha Bharati Academy, 2020.</ref>
* ''Lochamastaka''<ref name="Bhavaprakash" />


== Ayurvedic Pharmacological Properties ==
== Ayurvedic Pharmacological Properties ==
Line 130: Line 128:


== Major Phytoconstituents ==
== Major Phytoconstituents ==
The pharmacological efficacy of ''Trachyspermum ammi'' is predominantly attributed to its essential oil content, which ranges from 2% to 5%. The primary active constituent is '''thymol''' (accounting for 35% to 60% of the oil), accompanied by p-cymene, γ-terpinene, α-pinene, β-pinene, and carvacrol.
The pharmacological activity of ''Trachyspermum ammi'' (''Carum copticum'') is mainly attributed to its essential oil. The oil composition varies with geographical origin: thymol is the main component of oil from south Indian plants (reported up to 97.9%), whereas carvacrol, &gamma;-terpinene and ''p''-cymene are the main components of oil from other regions.<ref name="Boskabady2014" />


== Therapeutic Efficacy & Modern Scientific Research ==
== Therapeutic Efficacy & Modern Scientific Research ==
Modern pharmacological evaluations and clinical studies validate many of the traditional claims associated with *Trachyspermum ammi*. Its core therapeutic domains include:
Modern pharmacological studies support several of the traditional uses of ''Trachyspermum ammi'' (''Carum copticum''):


=== 1. Gastrointestinal and Carminative Activity (''Deepana'' & ''Pachana'') ===
=== 1. Gastrointestinal and Antispasmodic Activity (''Deepana'' & ''Pachana'') ===
* '''Traditional Use:''' Used for *Gulma* (abdominal lump), *Adhmana* (abdominal distention), *Aruchi* (anorexia), and *Sula* (colic pain).
* '''Traditional Use:''' Used for ''Gulma'' (abdominal lump), ''Adhmana'' (abdominal distention), ''Aruchi'' (anorexia) and ''Sula'' (colic pain).<ref name="API" />
* '''Mechanism & Scientific Evidence:''' Animal and in vitro studies demonstrate that the extract and essential oil of *T. ammi* exhibit significant anti-spasmodic (anticholinergic-like) and smooth-muscle relaxing properties. The carminative action is primarily mediated by thymol, which stimulates the secretion of gastric juices, enhances metabolic activity, and relieves flatulence and intestinal colic.<ref name="Tharakan2014">Tharakan, S. T., et al. "Evaluation of spasmolytic and bronchodilator activities of Trachyspermum ammi." Journal of Ethnopharmacology.</ref>
* '''Scientific Evidence:''' The aqueous-methanolic seed extract inhibited K<sup>+</sup>-induced contractions in isolated rabbit jejunum and shifted Ca<sup>2+</sup> dose-response curves to the right, similar to verapamil, indicating a calcium channel blocking (antispasmodic) effect.<ref name="Gilani2005" />


=== 2. Antimicrobial and Antifungal Efficacy (''Krumiroga'') ===
=== 2. Antimicrobial Efficacy (''Krumiroga'') ===
* '''Traditional Use:''' Employed in *Krumi roga* (parasitic and microbial infections).
* '''Traditional Use:''' Employed in ''Krumi roga'' (worms / microbial infections).<ref name="API" />
* '''Mechanism & Scientific Evidence:''' *T. ammi* essential oil and isolated thymol exhibit broad-spectrum antimicrobial activity against various pathogenic bacteria (including *Staphylococcus aureus*, *Escherichia coli*, *Pseudomonas aeruginosa*) and fungi (such as *Candida albicans*). The high phenolic content disrupts microbial cell membranes, causing leakage of intracellular constituents.<ref name="Khosravi2009">Khosravi, A. R., et al. "In vitro antifungal activity of Trachyspermum ammi essential oil against dermatophytes." Mycoses.</ref>
* '''Scientific Evidence:''' The essential oil of ''Carum copticum'' and its main compounds have been reported to have antibacterial and antifungal activity, assessed by MIC and MBC methods.<ref name="Kazemi2015" />


=== 3. Respiratory Support (''Hikka'' & Bronchodilation) ===
=== 3. Respiratory Support (''Swasa'' & Bronchodilation) ===
* '''Traditional Use:''' Used in respiratory distress, asthma (*Swasa*), and cough.
* '''Traditional Use:''' Used in asthma and dyspnea (''Swasa'') and cough; the plant is described in traditional medicine as anti-asthmatic and anti-dyspneic.<ref name="Boskabady2014" />
* '''Mechanism & Scientific Evidence:''' Pharmacological studies confirm that the bronchodilator activity of *T. ammi* is comparable to standard reference drugs (like theophylline/atropine). The relaxation of tracheal chains by thymol and carvacrol facilitates easier airflow, validating its traditional use in obstructive airway diseases.<ref name="Boskabady2014">Boskabady, M. H., et al. "Bronchodilator and anticough effects of Trachyspermum ammi." Research Reports.</ref>
* '''Scientific Evidence:''' The seed extract inhibited carbachol- and K<sup>+</sup>-induced contractions in isolated guinea-pig trachea and shifted the carbachol and histamine dose-response curves to the right, suggesting a non-specific bronchodilator effect possibly mediated through calcium channel blockade.<ref name="Gilani2005" /> Bronchodilator effects of ''C. copticum'' have also been reviewed.<ref name="Boskabady2014" />


=== 4. Antioxidant and Anti-inflammatory Properties ===
=== 4. Antioxidant and Anti-inflammatory Properties ===
* '''Mechanism & Scientific Evidence:''' *T. ammi* seeds possess significant free-radical scavenging abilities due to their high concentration of phenolic compounds. In vivo anti-inflammatory models show that extracts can reduce acute and chronic inflammation, partly by inhibiting inflammatory pathways and prostaglandin synthesis.<ref name="Javed2012">Javed, I., et al. "Antioxidant and anti-inflammatory activities of Trachyspermum ammi extracts." Phytotherapy Research.</ref>
* '''Scientific Evidence:''' The essential oil of ''Carum copticum'' showed antioxidant and anti-inflammatory properties in laboratory evaluation.<ref name="Kazemi2015" />
 
=== 5. Hepatoprotective and Antihypertensive Activity ===
* '''Scientific Evidence:''' In rats, pretreatment with the seed extract (500 mg/kg orally) prevented the rise in serum ALP and aminotransferases induced by paracetamol and carbon tetrachloride, and the extract caused a dose-dependent fall in arterial blood pressure in anaesthetized rats (3&ndash;100 mg/kg).<ref name="Gilani2005" />


== Summary of Therapeutic Profile ==
== Summary of Therapeutic Profile ==
Line 158: Line 159:
|-
|-
| '''Gastrointestinal Colic / Flatulence'''
| '''Gastrointestinal Colic / Flatulence'''
| Thymol, Carvacrol
| Seed extract (calcium antagonist constituents)
| Spasmolytic, Digestive stimulant, Carminative
| Antispasmodic (calcium channel blockade)<ref name="Gilani2005" />
|-
|-
| '''Microbial / Fungal Infections'''
| '''Microbial / Fungal Infections'''
| Essential Oils, Phenolics
| Essential oil
| Cell membrane disruption, Broad-spectrum antimicrobial
| Antibacterial, antifungal<ref name="Kazemi2015" />
|-
|-
| '''Respiratory Disorders / Asthma'''
| '''Respiratory Disorders / Asthma'''
| Thymol, p-cymene
| Seed extract
| Bronchodilation, Tracheal smooth muscle relaxation
| Bronchodilation, tracheal smooth muscle relaxation<ref name="Gilani2005" />
|-
|-
| '''Inflammation / Oxidative Stress'''
| '''Inflammation / Oxidative Stress'''
| Phenolic compounds
| Essential oil
| Free-radical scavenging, Anti-inflammatory pathway inhibition
| Antioxidant, anti-inflammatory<ref name="Kazemi2015" />
|}
|}


== Safety, Toxicity, and Dosage ==
== Safety, Toxicity, and Dosage ==
* '''Precautions:''' Due to the hot potency (''Ushna veerya'') and sharp qualities (''Tikshna guna''), it should be used cautiously in individuals with high Pitta aggravation or severe gastritis.
* '''Precautions:''' Due to the hot potency (''Ushna veerya'') and sharp qualities (''Tikshna guna''), it should be used cautiously in individuals with high Pitta aggravation or severe gastritis. This is a classical rationale rather than a clinical finding.
* '''Standard Therapeutic Dosage:'''  
* '''Standard Therapeutic Dosage:'''  
** ''Fruit Powder (Churna):'' 1 – 3 g daily.<ref name="API" />
** ''Fruit Powder (Churna):'' 1 – 3 g daily.<ref name="API" />
Line 181: Line 182:
== References ==
== References ==
{{Reflist|refs=
{{Reflist|refs=
<ref name="API">Anonymous. The Ayurvedic Pharmacopoeia of India. Department of Ayush, Ministry of Health and Family Welfare, Govt. of India, New Delhi, Part I. 1986; Volume I:02</ref>
<ref name="API">{{cite book |title=The Ayurvedic Pharmacopoeia of India |year=1986 |publisher=Department of Ayush, Ministry of Health and Family Welfare, Govt. of India |location=New Delhi |edition=Part I |volume=I |pages=02}}</ref> <!-- verify volume and page -->
<ref name="Bhavaprakash">Shri Bhavamishra, Bhavaprakash Nighantu, Haritakyadi Varga, verse no.- 77, Edited by Padmashree Prof. Krushnachandra Chunekar, Reprint Edition, Chaukhambha Bharati Academy, 2020.</ref>
<ref name="Bhavaprakash">{{cite book |last=Bhavamishra |first=Shri |title=Bhavaprakash Nighantu |others=Edited by Padmashree Prof. Krushnachandra Chunekar |edition=Reprint |publisher=Chaukhambha Bharati Academy |year=2020 |pages=Haritakyadi Varga, verse 77}}</ref>
<ref name="Tharakan2014">Tharakan, S. T., et al. "Evaluation of spasmolytic and bronchodilator activities of Trachyspermum ammi." Journal of Ethnopharmacology.</ref>
<ref name="Boskabady2014">{{cite journal |last1=Boskabady |first1=M. H. |last2=Alitaneh |first2=S. |last3=Alavinezhad |first3=A. |year=2014 |title=Carum copticum L.: a herbal medicine with various pharmacological effects |journal=BioMed Research International |volume=2014 |pages=569087 |doi=10.1155/2014/569087 |url=https://pmc.ncbi.nlm.nih.gov/articles/PMC4096002}}</ref>
<ref name="Khosravi2009">Khosravi, A. R., et al. "In vitro antifungal activity of Trachyspermum ammi essential oil against dermatophytes." Mycoses.</ref>
<ref name="Gilani2005">{{cite journal |last1=Gilani |first1=A. H. |last2=Jabeen |first2=Q. |last3=Ghayur |first3=M. N. |last4=Janbaz |first4=K. H. |last5=Akhtar |first5=M. S. |year=2005 |title=Studies on the antihypertensive, antispasmodic, bronchodilator and hepatoprotective activities of the Carum copticum seed extract |journal=Journal of Ethnopharmacology |volume=98 |issue=1–2 |pages=127–135 |doi=10.1016/j.jep.2005.01.017 |pmid=15763373 |url=https://pubmed.ncbi.nlm.nih.gov/15763373/}}</ref>
<ref name="Boskabady2014">Boskabady, M. H., et al. "Bronchodilator and anticough effects of Trachyspermum ammi." Research Reports.</ref>
<ref name="Kazemi2015">{{cite journal |last=Kazemi |first=M. |year=2015 |title=Phenolic profile, antimicrobial and anti-inflammatory activity of Carum copticum L. essential oil |journal=Bulgarian Chemical Communications |volume=47 |issue=1 |pages=149–155 |url=https://hero.epa.gov/hero/index.cfm/reference/details/reference_id/3440018}}</ref>
<ref name="Javed2012">Javed, I., et al. "Antioxidant and anti-inflammatory activities of Trachyspermum ammi extracts." Phytotherapy Research.</ref>
}}
}}


Latest revision as of 06:15, 6 October 2026


Dipyaka
Section/Chapter Herb database/Dipyaka
Botanical name(s) Carum copticum Benth. & Hook
Family Umbelliferae
Availability Available
Contributors Team Dravyaguna
Year of publication 2026
Publisher Charak Samhita Research, Training and Skill Development Centre
DOI Awaited

Carum copticum Benth. & Hook., commonly known as Dipyaka or Ajowan, is an annual herbaceous plant widely cultivated for its aromatic fruits. In Ayurveda, it is highly valued as a carminative, digestive stimulant, and Kapha-Vata pacifying medicine.[1] Trachyspermum ammi (L.) Sprague is regarded as a synonym of Carum copticum.[2]

English Name

Ajowan

Therapeutic Use

Gulma (abdominal lump), Aruchi (anorexia), Adhmana (abdominal distention), Hikka, Chardi (vomiting), Krumi roga (worms), Sula (pain)[1]

Synonyms in Charak Samhita

  • Dipyaka – Increases appetite.
  • Yavani
  • Bhutik
  • Dipya
  • Ajamodika

Synonyms in Bhavaprakasa Nighantu

  • Ajamoda
  • Kharashva – Fruits of ajamoda have an odor similar to a donkey.
  • Maayuro
  • Brahmakusha
  • Kaaravi
  • Lochamastaka[3]

Ayurvedic Pharmacological Properties

According to classical Ayurvedic pharmacodynamics (Rasa Panchaka), Dipyaka has the following properties:[1]

Sr. No. Pharmacological Criteria Properties (Ayurvedic Attributes)
1 Taste (Rasa) Pungent (Katu)
2 Potency (Veerya) Hot (Ushna)
3 Post-digestion Effect (Vipaka) Pungent (Katu)
4 Qualities (Guna) Light (Laghu), Rough (Ruksha), Sharp (Tikshna)
5 Dosha Action (Karma) Pacifies Kapha and Vata

Reference in Charak Samhita and its Actions

Dipyaka is prominently documented across multiple therapeutic chapters of the Charaka Samhita:

Sr. No. Reference in Charak Samhita Activity / Formulation / Therapeutic Use
1 Cha.Sa.Sutra Sthana 23/20 Santarpanajanya vikar chikitsa (management of over-nutrition disorder)
2 Cha.Sa.Sutra Sthana 27/170 Harita Varga (Class of green herbs)
3 Cha.Sa.Sutra Sthana 27/307 Krutanna Varga (Class on food articles)
4 Cha.Sa.Chikitsa Sthana 5/69 Ingredient of Hingusauvarchaladya ghrita
5 Cha.Sa.Chikitsa Sthana 5/71 Ingredient of Hapushadya ghrita
6 Cha.Sa.Chikitsa Sthana 5/86 Ingredient of Shatyadi Churna
7 Cha.Sa.Chikitsa Sthana 5/165 Pathya Diet in Gulma (wholesome food in treatment of abdominal lump)
8 Cha.Sa.Chikitsa Sthana 5/168 Vata, Kapha and Mala Anulomanarth
9 Cha.Sa.Chikitsa Sthana 6/27 Used for making decoction in Kaphaj prameha (diabetes)
10 Cha.Sa.Chikitsa Sthana 6/29 Used for making decoction in Kaphaj prameha (diabetes)
11 Cha.Sa.Chikitsa Sthana 6/38 Trikantakadhya Tail/Ghrit in Vata-kaphaj prameha (diabetes)
12 Cha.Sa.Chikitsa Sthana 6/41 Ingredient in Madhvasava
13 Cha.Sa.Chikitsa Sthana 9/54 Ingredient in Apara lasunadya Ghrita
14 Cha.Sa.Chikitsa Sthana 9/55 Ingredient in Apara lasunadya Ghrita
15 Cha.Sa.Chikitsa Sthana 12/36 Ingredient in Triphaladhyarishta
16 Cha.Sa.Chikitsa Sthana 12/43 Ingredient in Kshar Gudika
17 Cha.Sa.Chikitsa Sthana 12/55 Ingredient in Chitrakadi Ghrita
18 Cha.Sa.Chikitsa Sthana 13/103 In treatment of Kaphaja uadara roga
19 Cha.Sa.Chikitsa Sthana 13/125 As an ingredient of narayan churna
20 Cha.Sa.Chikitsa Sthana 14/63 As an ingredient of traushnadi churna

Dose

  • Powder (Churna): 1 – 3 g daily.[1]

Important Formulations

As per A.P.I.[1]

  • Ajamodarka
  • Ajmodadi churna

Current Availability

Available

Major Phytoconstituents

The pharmacological activity of Trachyspermum ammi (Carum copticum) is mainly attributed to its essential oil. The oil composition varies with geographical origin: thymol is the main component of oil from south Indian plants (reported up to 97.9%), whereas carvacrol, γ-terpinene and p-cymene are the main components of oil from other regions.[2]

Therapeutic Efficacy & Modern Scientific Research

Modern pharmacological studies support several of the traditional uses of Trachyspermum ammi (Carum copticum):

1. Gastrointestinal and Antispasmodic Activity (Deepana & Pachana)

  • Traditional Use: Used for Gulma (abdominal lump), Adhmana (abdominal distention), Aruchi (anorexia) and Sula (colic pain).[1]
  • Scientific Evidence: The aqueous-methanolic seed extract inhibited K+-induced contractions in isolated rabbit jejunum and shifted Ca2+ dose-response curves to the right, similar to verapamil, indicating a calcium channel blocking (antispasmodic) effect.[4]

2. Antimicrobial Efficacy (Krumiroga)

  • Traditional Use: Employed in Krumi roga (worms / microbial infections).[1]
  • Scientific Evidence: The essential oil of Carum copticum and its main compounds have been reported to have antibacterial and antifungal activity, assessed by MIC and MBC methods.[5]

3. Respiratory Support (Swasa & Bronchodilation)

  • Traditional Use: Used in asthma and dyspnea (Swasa) and cough; the plant is described in traditional medicine as anti-asthmatic and anti-dyspneic.[2]
  • Scientific Evidence: The seed extract inhibited carbachol- and K+-induced contractions in isolated guinea-pig trachea and shifted the carbachol and histamine dose-response curves to the right, suggesting a non-specific bronchodilator effect possibly mediated through calcium channel blockade.[4] Bronchodilator effects of C. copticum have also been reviewed.[2]

4. Antioxidant and Anti-inflammatory Properties

  • Scientific Evidence: The essential oil of Carum copticum showed antioxidant and anti-inflammatory properties in laboratory evaluation.[5]

5. Hepatoprotective and Antihypertensive Activity

  • Scientific Evidence: In rats, pretreatment with the seed extract (500 mg/kg orally) prevented the rise in serum ALP and aminotransferases induced by paracetamol and carbon tetrachloride, and the extract caused a dose-dependent fall in arterial blood pressure in anaesthetized rats (3–100 mg/kg).[4]

Summary of Therapeutic Profile

Therapeutic Applications of Trachyspermum ammi
Indication Active Biomolecules Primary Pharmacological Action
Gastrointestinal Colic / Flatulence Seed extract (calcium antagonist constituents) Antispasmodic (calcium channel blockade)[4]
Microbial / Fungal Infections Essential oil Antibacterial, antifungal[5]
Respiratory Disorders / Asthma Seed extract Bronchodilation, tracheal smooth muscle relaxation[4]
Inflammation / Oxidative Stress Essential oil Antioxidant, anti-inflammatory[5]

Safety, Toxicity, and Dosage

  • Precautions: Due to the hot potency (Ushna veerya) and sharp qualities (Tikshna guna), it should be used cautiously in individuals with high Pitta aggravation or severe gastritis. This is a classical rationale rather than a clinical finding.
  • Standard Therapeutic Dosage:
    • Fruit Powder (Churna): 1 – 3 g daily.[1]

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 The Ayurvedic Pharmacopoeia of India. I (Part I ed.). New Delhi: Department of Ayush, Ministry of Health and Family Welfare, Govt. of India. 1986. p. 02. 
  2. ↑ 2.0 2.1 2.2 2.3 Boskabady, M. H.; Alitaneh, S.; Alavinezhad, A. (2014). "Carum copticum L.: a herbal medicine with various pharmacological effects". BioMed Research International. 2014: 569087. doi:10.1155/2014/569087. 
  3. ↑ Bhavamishra, Shri (2020). Bhavaprakash Nighantu. Edited by Padmashree Prof. Krushnachandra Chunekar (Reprint ed.). Chaukhambha Bharati Academy. pp. Haritakyadi Varga, verse 77. 
  4. ↑ 4.0 4.1 4.2 4.3 4.4 Gilani, A. H.; Jabeen, Q.; Ghayur, M. N.; Janbaz, K. H.; Akhtar, M. S. (2005). "Studies on the antihypertensive, antispasmodic, bronchodilator and hepatoprotective activities of the Carum copticum seed extract". Journal of Ethnopharmacology. 98 (1–2): 127–135. PMID 15763373. doi:10.1016/j.jep.2005.01.017. 
  5. ↑ 5.0 5.1 5.2 5.3 Kazemi, M. (2015). "Phenolic profile, antimicrobial and anti-inflammatory activity of Carum copticum L. essential oil". Bulgarian Chemical Communications. 47 (1): 149–155. 

Herbs

This article is under development ..

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