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|label5 = Contributors
|label5 = Contributors
|data5 = [[Team Dravyaguna]]
|data5 = [[Team Dravyaguna]]
|label6 = Year of publication  
|label6 = Year of publication
|data6 = 2026
|data6 = 2026
|label7 = Publisher  
|label7 = Publisher
|data7 = [[Charak Samhita Research, Training and Skill Development Centre]]
|data7 = [[Charak Samhita Research, Training and Skill Development Centre]]
|label8 = DOI  
|label8 = DOI
|data8 = Awaited
|data8 = Awaited
}}
}}


'''[https://en.wikipedia.org/wiki/Pomegranate Punica granatum L.]''', popularly known as '''Dadima''' (Pomegranate), is a large deciduous shrub or small tree belonging to the family Lythraceae. It is highly revered in [[Ayurveda]] for its versatile culinary and therapeutic properties, acting as a profound heart-healthy tonic (*hridya*) and digestive aid.
'''[https://en.wikipedia.org/wiki/Pomegranate Punica granatum L.]''', popularly known as '''Dadima''' (Pomegranate), is a large deciduous shrub or small tree belonging to the family Lythraceae. It is highly revered in [[Ayurveda]] for its culinary and therapeutic uses, as a heart-healthy tonic (''hridya'') and digestive aid.


==English name ==  
==English name==
Pomegranate
Pomegranate


==Therapeutic uses==
==Therapeutic uses==
* '''Sweet fruit (swadu):''' Beneficial in burning sensations (*daha*), excessive thirst (*trishna*), fever (*jwara*), enhancing reproductive constituents (*shukrala*), light to digest (*laghu*), and reduces bad mouth odour (*mukhagandhaghna*).
* '''Sweet fruit (swadu):''' Beneficial in burning sensations (''daha''), excessive thirst (''trishna''), fever (''jwara''), enhancing reproductive constituents (''shukrala''), light to digest (''laghu''), and reduces bad mouth odour (''mukhagandhaghna'').
* '''Sweet and sour fruit (swaduamla):''' Beneficial for stimulating digestion (*dipana*), improving taste (*ruchya*), and slightly elevates pitta dosha.
* '''Sweet and sour fruit (swaduamla):''' Beneficial for stimulating digestion (''dipana''), improving taste (''ruchya''), and slightly elevates pitta dosha.
* '''Sour fruit (amla):''' Aggravates pitta dosha and alleviates vata and kapha dosha.
* '''Sour fruit (amla):''' Aggravates pitta dosha and alleviates vata and kapha dosha.


==Identification characters==
==Identification characters==
It is a large deciduous shrub or small tree with shining, oblanceolate glabrous leaves, red-colored flowers with 5–7 petals, and a globose fruit.<ref name="ref1">Anonymous. The Ayurvedic Pharmacopoeia of India. Department of Ayush, Ministry of Health and Family welfare, Govt. of India, New Delhi, Part I. 2001; Volume III: 45-46.</ref>
It is a large deciduous shrub or small tree with shining, oblanceolate glabrous leaves, red-colored flowers with 5–7 petals, and a globose fruit.<ref name="ref1" />


[[File:Punica_granatum.jpg|thumb|Dadima (Punica granatum)]]
[[File:Punica_granatum.jpg|thumb|Dadima (Punica granatum)]]


== Botanical Profile & Traditional Context ==
==Traditional Context==
In traditional Ayurvedic texts, Dadima is classified into three types based on taste: sweet (*swadu*), sweet-sour (*swaduamla*), and sour (*amla*). It plays a crucial role in dietary prescriptions (*Pathya*) and complex formulations due to its ability to pacify Vata, Pitta, and Kapha doshas depending on its specific variety.<ref name="ref2">Shri Bhavamishra, Bhavaprakash Nighantu, Haritakyadi Varga, Verse no. 35-38, Edited by Padmashree Pro. Krushnachandra Chunekar, Reprint Edition, Chaukhambha Bharati Academy, 2015.</ref>
In traditional Ayurvedic texts, Dadima is classified into three types based on taste: sweet (''swadu''), sweet-sour (''swaduamla'') and sour (''amla''). It has an important role in dietary prescriptions (''Pathya'') and in many formulations, and pacifies Vata, Pitta and Kapha doshas depending on its variety.<ref name="ref2" />


== Synonyms in Charak Samhita==
==Synonyms in Charak Samhita==
Dadima, Karaka, Dantabija, Lohitapushpaka
Dadima, Karaka, Dantabija, Lohitapushpaka


==Additional Synonyms in Bhavaprakasha Nighantu==
==Additional Synonyms in Bhavaprakasha Nighantu==
* '''Dadima:''' Useful in many conditions.<ref name="ref2"/>
* '''Dadima:''' Useful in many conditions.<ref name="ref2" />
* '''Dantabija:''' Seeds resemble teeth.<ref name="ref2"/>
* '''Dantabija:''' Seeds resemble teeth.<ref name="ref2" />
* '''Lohitapushpaka:''' Flowers are red in color.<ref name="ref2"/>
* '''Lohitapushpaka:''' Flowers are red in color.<ref name="ref2" />


==Types (Bheda)==
==Types (Bheda)==
# Swadu (Sweet)<ref name="ref2"/>
# Swadu (Sweet)<ref name="ref2" />
# Swaduamla (Sweet and sour)<ref name="ref2"/>
# Swaduamla (Sweet and sour)<ref name="ref2" />
# Amla (Sour)<ref name="ref2"/>
# Amla (Sour)<ref name="ref2" />


== Ayurvedic pharmacological properties ==  
==Ayurvedic pharmacological properties==


{| class="wikitable"
{| class="wikitable"
|+ Properties  
|+ Properties
|-
|-
! Sr.no. !! Pharmacological criteria !! Properties
! Sr.no. !! Pharmacological criteria !! Properties
|-
|-
| 1 || Taste ([[rasa]]) || Sweet (madhura), Astringent (kashaya), Sour (amla)<ref name="ref2"/>
| 1 || Taste ([[rasa]]) || Sweet (madhura), Astringent (kashaya), Sour (amla)<ref name="ref2" />
|-
|-
| 2 || Potency ([[veerya]]) || Not too hot (anushna)<ref name="ref2"/>
| 2 || Potency ([[veerya]]) || Not too hot (anushna)<ref name="ref2" />
|-
|-
| 3 || Post digestion effect ([[vipaka]]) || Sweet (madhura)<ref name="ref2"/>
| 3 || Post digestion effect ([[vipaka]]) || Sweet (madhura)<ref name="ref2" />
|-
|-
| 4 || Qualities ([[guna]])|| Light (laghu), Unctuous (snigdha)<ref name="ref2"/>
| 4 || Qualities ([[guna]]) || Light (laghu), Unctuous (snigdha)<ref name="ref2" />
|-
|-
| 5 || Actions ([[karma]]) || Reduces [[vata]], [[pitta]] and [[kapha]]<ref name="ref2"/>
| 5 || Actions ([[karma]]) || Reduces [[vata]], [[pitta]] and [[kapha]]<ref name="ref2" />
|-
|-
|}
|}


== Reference in Charak Samhita and its actions ==  
==Reference in Charak Samhita and its actions==


{| class="wikitable"
{| class="wikitable"
|+ Herbs and their activities
|+ Herbs and their activities
|-
|-
! Sr.no. !! Reference in Charak Samhita !! Activity  
! Sr.no. !! Reference in Charak Samhita !! Activity
|-
|-
| 1 || Cha.Sa.[[Sutra Sthana]] 2/19 || Pachani-Grahi yavagu
| 1 || Cha.Sa.[[Sutra Sthana]] 2/19 || Pachani-Grahi yavagu
Line 249: Line 249:


==Dose==
==Dose==
* 5 to 10 g of the drug in powder form or fresh juice as required.<ref name="ref1"/>
* 5 to 10 g of the drug in powder form or fresh juice as required.<ref name="ref1" />


==Important Formulations==
==Important Formulations==
Line 258: Line 258:
* Shukramatruka Vati
* Shukramatruka Vati


== Current availability==  
==Current availability==
Available
Available
* '''In India –''' Found growing wild in the valley and outer hills of the Himalayas between 900–1800 m, and cultivated widely across many parts of the country.<ref name="ref1"/>
* '''In India –''' Found growing wild in the valley and outer hills of the Himalayas between 900–1800 m, and cultivated widely across many parts of the country.<ref name="ref1" />
* '''Out of India –''' Central Asia, the Himalayas, the Mediterranean, the Middle East, California, Arizona, and South Asia.<ref name="ref1"/>
* '''Out of India –''' Central Asia, the Himalayas, the Mediterranean, the Middle East, California, Arizona, and South Asia.<ref name="ref1" />


== Phytochemical Composition ==
==Phytoconstituents==
Pomegranate plant parts (including fruit, seeds, peel, and leaves) contain a rich profile of bioactive secondary metabolites:
Different parts of ''Punica granatum'' (fruit peel, aril and juice, seed, flower, leaf, bark and heartwood) contain the following major classes of phytochemicals:<ref name="Wu2017" />
* '''Hydrolyzable Tannins:''' Punicalagin, punicalin, ellagic acid, and gallic acid.<ref name="ref3">{{cite journal |last1=Jurenka |first1=J. S. |year=2008 |title=Therapeutic applications of pomegranate (Punica granatum L.): a review |journal=Alternative Medicine Review |volume=13 |issue=2 |pages=128–144}}</ref>
* '''Hydrolyzable tannins:''' ellagitannins (e.g. punicalagin, punicalin) and gallotannins, abundant in the fruit peel.
* '''Flavonoids & Anthocyanins:''' Delphinidin, cyanidin, and pelargonidin glycosides responsible for its deep red coloration.<ref name="ref3"/>
* '''Ellagic acid:''' free ellagic acid, its methylated forms and glycosidic derivatives.
* '''Other Constituents:''' Alkaloids, triterpenoids, saponins, and essential sterols.<ref name="ref3"/>
* '''Flavonoids:''' chalcones, flavanones, flavones, flavonols, anthocyanins (responsible for the red colour), flavan-3-ols and procyanidins.
* '''Alkaloids:''' present in the bark.
* '''Steroids and lipids:''' steroid hormones and seed-oil lipids such as monoacylglycerols and triglycerides.


== Pharmacological Activities & Therapeutic Efficacy ==
==Pharmacological Activities and Therapeutic Efficacy==
=== Cardiovascular and Metabolic Protection ===
All studies below are preclinical or small human studies on pomegranate preparations. Results with juice or peel extract should not be taken as proof of the effect of the Ayurvedic dosage forms.
Dadima is universally praised for its cardiotonic (*hridya*) properties, matching its extensive use in modern clinical studies.
* '''Mechanism:''' High concentrations of punicalagins and ellagic acid act as potent antioxidants that inhibit low-density lipoprotein (LDL) oxidation, improve endothelial function, and support healthy blood pressure levels.<ref name="ref4">{{cite journal |last1=Aviram |first1=M. |last2=Dornfeld |first2=L. |last3=Rosenblat |first3=M. |year=2000 |title=Pomegranate juice consumption reduces oxidative stress, atherogenic modifications to LDL, and platelet aggregation: studies in humans and in atherosclerotic mice |journal=The American Journal of Clinical Nutrition |volume=71 |issue=5 |pages=1062–1076}}</ref>
* '''Scientific Evidence:''' Clinical trials indicate that regular pomegranate supplementation significantly reduces systolic blood pressure, ameliorates hyperlipidemia, and provides protective benefits against metabolic syndrome and coronary heart disease.<ref name="ref4"/>


=== Gastrointestinal and Anti-Diarrheal Efficacy ===
===Overview of therapeutic applications===
Traditional references emphasize its wide application in *Atisara* (diarrhoea) and digestive dysfunctions.
Pomegranate constituents have been reported to have antioxidant, anticarcinogenic and anti-inflammatory properties, with research on cancer, cardiovascular disease, diabetes, dental conditions, bacterial infections and other disorders.<ref name="Jurenka2008" />
* '''Mechanism:''' The astringent tannins precipitate proteins in the intestinal mucosa, reducing excessive fluid secretion and tightening intestinal walls.<ref name="ref5">{{cite journal |last1=Qnais |first1=E. S. |last2=Elhaj |first2=H. A. |last3=Abu-Dieyeh |first3=Z. H. |last4=Abdalla |first4=S. S. |year=2007 |title=Antidiarrheal activity of the aqueous extract of Punica granatum (pomegranate) peels |journal=Pharmaceutical Biology |volume=45 |issue=9 |pages=715–720}}</ref>
* '''Scientific Evidence:''' Literature notes over 100 traditional formulations utilizing Dadima for diarrheal conditions, supported by its antimicrobial and anti-inflammatory properties within the gut.<ref name="ref5"/>


=== Anti-Inflammatory and Anticancer Actions ===
===Cardiovascular protection (Hridya)===
Modern phytochemical evaluations highlight the extensive healing properties of pomegranate extracts.
In healthy male volunteers and in atherosclerotic apolipoprotein E-deficient mice, pomegranate juice consumption had potent antioxidant effects against lipid peroxidation in plasma and lipoproteins. In humans it decreased LDL susceptibility to aggregation and retention and raised the activity of serum paraoxonase by about 20%.<ref name="Aviram2000" />
* '''Mechanism:''' Bioactive polyphenols downregulate pro-inflammatory transcription factors (such as NF-$\kappa$B) and suppress oxidative stress pathways.<ref name="ref6">{{cite journal |last1=Lansky |first1=E. P. |last2=Newman |first2=R. A. |year=2007 |title=Punica granatum (pomegranate) and its potential for prevention and treatment of inflammation and cancer |journal=Journal of Ethnopharmacology |volume=109 |issue=2 |pages=177–206}}</ref>
* '''Scientific Evidence:''' Research reports inhibitory effects of pomegranate extracts on various cancer cell proliferation lines, alongside strong multi-organ protective responses against oxidative damage.<ref name="ref6"/>


== Safety, Toxicity, and Dosage ==
===Antidiarrhoeal activity (Atisara)===
* '''Acute Toxicity:''' Dadima is exceptionally safe for daily nutritional and therapeutic use.<ref name="ref3"/>
The aqueous extract of the peel (100–400 mg/kg) reduced castor-oil-induced diarrhoea, enteropooling and gastrointestinal transit in rats in a dose-dependent manner, and inhibited the spontaneous movement of the isolated rat ileum. The extract contained tannins, flavonoids and alkaloids.<ref name="Qnais2007" />
* '''Precautions:''' The only classical contraindication noted in Ayurvedic literature is its avoidance during specific treatments like Khandakadya Lauha administration in *raktapitta* conditions.
* '''Standard Therapeutic Dosage:'''
** ''Fruit Juice / Fresh Arils:'' As desired or 30–50 ml.<ref name="ref1"/>
** ''Powder (Churna):'' 5–10 g daily.<ref name="ref1"/>


== Summary of Therapeutic Profile ==
===Anti-inflammatory and anticancer potential===
Juice and peel possess potent antioxidant properties, and the phytochemistry and pharmacological actions of the different parts of the plant suggest a wide range of applications in preventing and treating cancer and other diseases in which chronic inflammation plays a role.<ref name="Lansky2007" />
 
==Safety, Toxicity and Dosage==
* '''Toxicity:''' The aqueous peel extract had an intraperitoneal LD50 of 1321 ± 15 mg/kg in mice.<ref name="Qnais2007" /> No other safety data are cited here; oral safety of the traditional dosage forms has not been verified for this monograph.
* '''Precautions (classical, no experimental reference cited):''' The only classical contraindication noted in Ayurvedic literature is its avoidance during specific treatments like Khandakadya Lauha administration in ''raktapitta'' conditions.
* '''Standard therapeutic dose:''' Fruit juice or fresh arils as desired or 30–50 ml; powder (churna) 5–10 g daily (see Dose above).<ref name="ref1" />
 
==Summary of Therapeutic Profile==
{| class="wikitable sortable" style="text-align: left;"
{| class="wikitable sortable" style="text-align: left;"
|+ Therapeutic Applications of ''Punica granatum''
|+ Therapeutic applications of ''Punica granatum'' (preclinical and small human studies)
! Indication
! Indication
! Active Biomolecules
! Part / preparation studied
! Primary Pharmacological Action
! Principal finding
|-
|-
| '''Cardiovascular Health / Hridroga'''
| '''Cardiovascular health / Hridroga'''
| Punicalagin, Ellagic acid
| Juice
| Antioxidant, Anti-atherogenic, Vasoprotective
| Antioxidant effects; reduced LDL aggregation and retention, raised paraoxonase activity
|-
|-
| '''Diarrhoea / Atisara'''
| '''Diarrhoea / Atisara'''
| Tannins, Polyphenols
| Aqueous peel extract
| Astringent, Antimicrobial, Intestinal binder
| Reduced castor-oil diarrhoea, enteropooling and intestinal transit in rats
|-
| '''Inflammation and cancer'''
| Juice, peel and other parts
| Antioxidant and anti-inflammatory potential (review evidence)
|-
|-
| '''Metabolic Syndrome & Obesity'''
| Anthocyanins, Flavonoids
| Lipid-lowering, Anti-inflammatory
|}
|}


== References ==
==References==
{{Reflist|refs=
{{Reflist|refs=
<ref name="ref1">Anonymous. The Ayurvedic Pharmacopoeia of India. Department of Ayush, Ministry of Health and Family welfare, Govt. of India, New Delhi, Part I. 2001; Volume III: 45-46.</ref>
<ref name="ref1">Anonymous. The Ayurvedic Pharmacopoeia of India. Department of Ayush, Ministry of Health and Family welfare, Govt. of India, New Delhi, Part I. 2001; Volume III: 45-46.</ref>
<ref name="ref2">Shri Bhavamishra, Bhavaprakash Nighantu, Haritakyadi Varga, Verse no. 35-38, Edited by Padmashree Pro. Krushnachandra Chunekar, Reprint Edition, Chaukhambha Bharati Academy, 2015.</ref>
<ref name="ref2">Shri Bhavamishra, Bhavaprakash Nighantu, Haritakyadi Varga, Verse no. 35-38, Edited by Padmashree Pro. Krushnachandra Chunekar, Reprint Edition, Chaukhambha Bharati Academy, 2015.</ref>
<ref name="ref3">{{cite journal |last1=Jurenka |first1=J. S. |year=2008 |title=Therapeutic applications of pomegranate (Punica granatum L.): a review |journal=Alternative Medicine Review |volume=13 |issue=2 |pages=128–144}}</ref>
<ref name="Wu2017">{{cite journal |last1=Wu |first1=S. |last2=Tian |first2=L. |year=2017 |title=Diverse phytochemicals and bioactivities in the ancient fruit and modern functional food pomegranate (Punica granatum) |journal=Molecules |volume=22 |issue=10 |pages=1606 |doi=10.3390/molecules22101606}}</ref>
<ref name="ref4">{{cite journal |last1=Aviram |first1=M. |last2=Dornfeld |first2=L. |last3=Rosenblat |first3=M. |year=2000 |title=Pomegranate juice consumption reduces oxidative stress, atherogenic modifications to LDL, and platelet aggregation: studies in humans and in atherosclerotic mice |journal=The American Journal of Clinical Nutrition |volume=71 |issue=5 |pages=1062–1076}}</ref>
<ref name="Jurenka2008">{{cite journal |last1=Jurenka |first1=J. S. |year=2008 |title=Therapeutic applications of pomegranate (Punica granatum L.): a review |journal=Alternative Medicine Review |volume=13 |issue=2 |pages=128–144}}</ref>
<ref name="ref5">{{cite journal |last1=Qnais |first1=E. S. |last2=Elhaj |first2=H. A. |last3=Abu-Dieyeh |first3=Z. H. |last4=Abdalla |first4=S. S. |year=2007 |title=Antidiarrheal activity of the aqueous extract of Punica granatum (pomegranate) peels |journal=Pharmaceutical Biology |volume=45 |issue=9 |pages=715–720}}</ref>
<ref name="Aviram2000">{{cite journal |last1=Aviram |first1=M. |last2=Dornfeld |first2=L. |last3=Rosenblat |first3=M. |last4=Volkova |first4=N. |last5=Kaplan |first5=M. |last6=Coleman |first6=R. |last7=Hayek |first7=T. |last8=Presser |first8=D. |last9=Fuhrman |first9=B. |year=2000 |title=Pomegranate juice consumption reduces oxidative stress, atherogenic modifications to LDL, and platelet aggregation: studies in humans and in atherosclerotic apolipoprotein E-deficient mice |journal=The American Journal of Clinical Nutrition |volume=71 |issue=5 |pages=1062–1076 |doi=10.1093/ajcn/71.5.1062}}</ref>
<ref name="ref6">{{cite journal |last1=Lansky |first1=E. P. |last2=Newman |first2=R. A. |year=2007 |title=Punica granatum (pomegranate) and its potential for prevention and treatment of inflammation and cancer |journal=Journal of Ethnopharmacology |volume=109 |issue=2 |pages=177–206}}</ref>
<ref name="Qnais2007">{{cite journal |last1=Qnais |first1=E. Y. |last2=Elokda |first2=A. S. |last3=Abu Ghalyun |first3=Y. Y. |last4=Abdulla |first4=F. A. |year=2007 |title=Antidiarrheal activity of the aqueous extract of Punica granatum (pomegranate) peels |journal=Pharmaceutical Biology |volume=45 |issue=9 |pages=715–720 |doi=10.1080/13880200701575304}}</ref>
<ref name="Lansky2007">{{cite journal |last1=Lansky |first1=E. P. |last2=Newman |first2=R. A. |year=2007 |title=Punica granatum (pomegranate) and its potential for prevention and treatment of inflammation and cancer |journal=Journal of Ethnopharmacology |volume=109 |issue=2 |pages=177–206 |doi=10.1016/j.jep.2006.09.006}}</ref>
}}
}}


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