Talk:Dadima: Difference between revisions
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|label5 = Contributors | |label5 = Contributors | ||
|data5 = [[Team Dravyaguna]] | |data5 = [[Team Dravyaguna]] | ||
|label6 = Year of publication | |label6 = Year of publication | ||
|data6 = | |data6 = 2026 | ||
|label7 = Publisher | |label7 = Publisher | ||
|data7 = | |data7 = [[Charak Samhita Research, Training and Skill Development Centre]] | ||
|label8 = DOI | |label8 = DOI | ||
|data8 | |data8 = Awaited | ||
}} | }} | ||
'''[https://en.wikipedia.org/wiki/Pomegranate Punica granatum L.]''', popularly known as '''Dadima''' (Pomegranate), is a large deciduous shrub or small tree belonging to the family Lythraceae. It is highly revered in [[Ayurveda]] for its | '''[https://en.wikipedia.org/wiki/Pomegranate Punica granatum L.]''', popularly known as '''Dadima''' (Pomegranate), is a large deciduous shrub or small tree belonging to the family Lythraceae. It is highly revered in [[Ayurveda]] for its culinary and therapeutic uses, as a heart-healthy tonic (''hridya'') and digestive aid. | ||
==English name == | ==English name== | ||
Pomegranate | Pomegranate | ||
==Therapeutic uses== | ==Therapeutic uses== | ||
* '''Sweet fruit (swadu):''' Beneficial in burning sensations ( | * '''Sweet fruit (swadu):''' Beneficial in burning sensations (''daha''), excessive thirst (''trishna''), fever (''jwara''), enhancing reproductive constituents (''shukrala''), light to digest (''laghu''), and reduces bad mouth odour (''mukhagandhaghna''). | ||
* '''Sweet and sour fruit (swaduamla):''' Beneficial for stimulating digestion ( | * '''Sweet and sour fruit (swaduamla):''' Beneficial for stimulating digestion (''dipana''), improving taste (''ruchya''), and slightly elevates pitta dosha. | ||
* '''Sour fruit (amla):''' Aggravates pitta dosha and alleviates vata and kapha dosha. | * '''Sour fruit (amla):''' Aggravates pitta dosha and alleviates vata and kapha dosha. | ||
==Identification characters== | ==Identification characters== | ||
It is a large deciduous shrub or small tree with shining, oblanceolate glabrous leaves, red-colored flowers with 5–7 petals, and a globose fruit.<ref name="ref1" | It is a large deciduous shrub or small tree with shining, oblanceolate glabrous leaves, red-colored flowers with 5–7 petals, and a globose fruit.<ref name="ref1" /> | ||
[[File:Punica_granatum.jpg|thumb|Dadima (Punica granatum)]] | [[File:Punica_granatum.jpg|thumb|Dadima (Punica granatum)]] | ||
== | ==Traditional Context== | ||
In traditional Ayurvedic texts, Dadima is classified into three types based on taste: sweet ( | In traditional Ayurvedic texts, Dadima is classified into three types based on taste: sweet (''swadu''), sweet-sour (''swaduamla'') and sour (''amla''). It has an important role in dietary prescriptions (''Pathya'') and in many formulations, and pacifies Vata, Pitta and Kapha doshas depending on its variety.<ref name="ref2" /> | ||
== Synonyms in Charak Samhita== | ==Synonyms in Charak Samhita== | ||
Dadima, Karaka, Dantabija, Lohitapushpaka | Dadima, Karaka, Dantabija, Lohitapushpaka | ||
==Additional Synonyms in Bhavaprakasha Nighantu== | ==Additional Synonyms in Bhavaprakasha Nighantu== | ||
* '''Dadima:''' Useful in many conditions.<ref name="ref2"/> | * '''Dadima:''' Useful in many conditions.<ref name="ref2" /> | ||
* '''Dantabija:''' Seeds resemble teeth.<ref name="ref2"/> | * '''Dantabija:''' Seeds resemble teeth.<ref name="ref2" /> | ||
* '''Lohitapushpaka:''' Flowers are red in color.<ref name="ref2"/> | * '''Lohitapushpaka:''' Flowers are red in color.<ref name="ref2" /> | ||
==Types (Bheda)== | ==Types (Bheda)== | ||
# Swadu (Sweet)<ref name="ref2"/> | # Swadu (Sweet)<ref name="ref2" /> | ||
# Swaduamla (Sweet and sour)<ref name="ref2"/> | # Swaduamla (Sweet and sour)<ref name="ref2" /> | ||
# Amla (Sour)<ref name="ref2"/> | # Amla (Sour)<ref name="ref2" /> | ||
== Ayurvedic pharmacological properties == | ==Ayurvedic pharmacological properties== | ||
{| class="wikitable" | {| class="wikitable" | ||
|+ Properties | |+ Properties | ||
|- | |- | ||
! Sr.no. !! Pharmacological criteria !! Properties | ! Sr.no. !! Pharmacological criteria !! Properties | ||
|- | |- | ||
| 1 || Taste ([[rasa]]) | | 1 || Taste ([[rasa]]) || Sweet (madhura), Astringent (kashaya), Sour (amla)<ref name="ref2" /> | ||
|- | |- | ||
| 2 || Potency ([[veerya]]) || Not too hot (anushna)<ref name="ref2"/> | | 2 || Potency ([[veerya]]) || Not too hot (anushna)<ref name="ref2" /> | ||
|- | |- | ||
| 3 || Post digestion effect ([[vipaka]]) || Sweet (madhura)<ref name="ref2"/> | | 3 || Post digestion effect ([[vipaka]]) || Sweet (madhura)<ref name="ref2" /> | ||
|- | |- | ||
| 4 || Qualities ([[guna]])|| Light (laghu), Unctuous (snigdha)<ref name="ref2"/> | | 4 || Qualities ([[guna]]) || Light (laghu), Unctuous (snigdha)<ref name="ref2" /> | ||
|- | |- | ||
| 5 || Actions ([[karma]]) || Reduces [[vata]], [[pitta]] and [[kapha]]<ref name="ref2"/> | | 5 || Actions ([[karma]]) || Reduces [[vata]], [[pitta]] and [[kapha]]<ref name="ref2" /> | ||
|- | |- | ||
|} | |} | ||
== Reference in Charak Samhita and its actions == | ==Reference in Charak Samhita and its actions== | ||
{| class="wikitable" | {| class="wikitable" | ||
|+ Herbs and their activities | |+ Herbs and their activities | ||
|- | |- | ||
! Sr.no. !! Reference in Charak Samhita !! Activity | ! Sr.no. !! Reference in Charak Samhita !! Activity | ||
|- | |- | ||
| 1 || Cha.Sa.[[Sutra Sthana]] 2/19 || Pachani-Grahi yavagu | | 1 || Cha.Sa.[[Sutra Sthana]] 2/19 || Pachani-Grahi yavagu | ||
| Line 249: | Line 249: | ||
==Dose== | ==Dose== | ||
* 5 to 10 g of the drug in powder form or fresh juice as required.<ref name="ref1"/> | * 5 to 10 g of the drug in powder form or fresh juice as required.<ref name="ref1" /> | ||
==Important Formulations== | ==Important Formulations== | ||
| Line 258: | Line 258: | ||
* Shukramatruka Vati | * Shukramatruka Vati | ||
== Current availability== | ==Current availability== | ||
Available | Available | ||
* '''In India –''' Found growing wild in the valley and outer hills of the Himalayas between 900–1800 m, and cultivated widely across many parts of the country.<ref name="ref1"/> | * '''In India –''' Found growing wild in the valley and outer hills of the Himalayas between 900–1800 m, and cultivated widely across many parts of the country.<ref name="ref1" /> | ||
* '''Out of India –''' Central Asia, the Himalayas, the Mediterranean, the Middle East, California, Arizona, and South Asia.<ref name="ref1"/> | * '''Out of India –''' Central Asia, the Himalayas, the Mediterranean, the Middle East, California, Arizona, and South Asia.<ref name="ref1" /> | ||
== | ==Phytoconstituents== | ||
Different parts of ''Punica granatum'' (fruit peel, aril and juice, seed, flower, leaf, bark and heartwood) contain the following major classes of phytochemicals:<ref name="Wu2017" /> | |||
* '''Hydrolyzable | * '''Hydrolyzable tannins:''' ellagitannins (e.g. punicalagin, punicalin) and gallotannins, abundant in the fruit peel. | ||
* '''Flavonoids | * '''Ellagic acid:''' free ellagic acid, its methylated forms and glycosidic derivatives. | ||
* ''' | * '''Flavonoids:''' chalcones, flavanones, flavones, flavonols, anthocyanins (responsible for the red colour), flavan-3-ols and procyanidins. | ||
* '''Alkaloids:''' present in the bark. | |||
* '''Steroids and lipids:''' steroid hormones and seed-oil lipids such as monoacylglycerols and triglycerides. | |||
== Pharmacological Activities | ==Pharmacological Activities and Therapeutic Efficacy== | ||
All studies below are preclinical or small human studies on pomegranate preparations. Results with juice or peel extract should not be taken as proof of the effect of the Ayurvedic dosage forms. | |||
=== | ===Overview of therapeutic applications=== | ||
Pomegranate constituents have been reported to have antioxidant, anticarcinogenic and anti-inflammatory properties, with research on cancer, cardiovascular disease, diabetes, dental conditions, bacterial infections and other disorders.<ref name="Jurenka2008" /> | |||
=== | ===Cardiovascular protection (Hridya)=== | ||
In healthy male volunteers and in atherosclerotic apolipoprotein E-deficient mice, pomegranate juice consumption had potent antioxidant effects against lipid peroxidation in plasma and lipoproteins. In humans it decreased LDL susceptibility to aggregation and retention and raised the activity of serum paraoxonase by about 20%.<ref name="Aviram2000" /> | |||
== | ===Antidiarrhoeal activity (Atisara)=== | ||
The aqueous extract of the peel (100–400 mg/kg) reduced castor-oil-induced diarrhoea, enteropooling and gastrointestinal transit in rats in a dose-dependent manner, and inhibited the spontaneous movement of the isolated rat ileum. The extract contained tannins, flavonoids and alkaloids.<ref name="Qnais2007" /> | |||
== Summary of Therapeutic Profile == | ===Anti-inflammatory and anticancer potential=== | ||
Juice and peel possess potent antioxidant properties, and the phytochemistry and pharmacological actions of the different parts of the plant suggest a wide range of applications in preventing and treating cancer and other diseases in which chronic inflammation plays a role.<ref name="Lansky2007" /> | |||
==Safety, Toxicity and Dosage== | |||
* '''Toxicity:''' The aqueous peel extract had an intraperitoneal LD50 of 1321 ± 15 mg/kg in mice.<ref name="Qnais2007" /> No other safety data are cited here; oral safety of the traditional dosage forms has not been verified for this monograph. | |||
* '''Precautions (classical, no experimental reference cited):''' The only classical contraindication noted in Ayurvedic literature is its avoidance during specific treatments like Khandakadya Lauha administration in ''raktapitta'' conditions. | |||
* '''Standard therapeutic dose:''' Fruit juice or fresh arils as desired or 30–50 ml; powder (churna) 5–10 g daily (see Dose above).<ref name="ref1" /> | |||
==Summary of Therapeutic Profile== | |||
{| class="wikitable sortable" style="text-align: left;" | {| class="wikitable sortable" style="text-align: left;" | ||
|+ Therapeutic | |+ Therapeutic applications of ''Punica granatum'' (preclinical and small human studies) | ||
! Indication | ! Indication | ||
! | ! Part / preparation studied | ||
! | ! Principal finding | ||
|- | |- | ||
| '''Cardiovascular | | '''Cardiovascular health / Hridroga''' | ||
| | | Juice | ||
| Antioxidant, | | Antioxidant effects; reduced LDL aggregation and retention, raised paraoxonase activity | ||
|- | |- | ||
| '''Diarrhoea / Atisara''' | | '''Diarrhoea / Atisara''' | ||
| | | Aqueous peel extract | ||
| | | Reduced castor-oil diarrhoea, enteropooling and intestinal transit in rats | ||
|- | |||
| '''Inflammation and cancer''' | |||
| Juice, peel and other parts | |||
| Antioxidant and anti-inflammatory potential (review evidence) | |||
|- | |- | ||
|} | |} | ||
== References == | ==References== | ||
{{Reflist|refs= | {{Reflist|refs= | ||
<ref name="ref1">Anonymous. The Ayurvedic Pharmacopoeia of India. Department of Ayush, Ministry of Health and Family welfare, Govt. of India, New Delhi, Part I. 2001; Volume III: 45-46.</ref> | <ref name="ref1">Anonymous. The Ayurvedic Pharmacopoeia of India. Department of Ayush, Ministry of Health and Family welfare, Govt. of India, New Delhi, Part I. 2001; Volume III: 45-46.</ref> | ||
<ref name="ref2">Shri Bhavamishra, Bhavaprakash Nighantu, Haritakyadi Varga, Verse no. 35-38, Edited by Padmashree Pro. Krushnachandra Chunekar, Reprint Edition, Chaukhambha Bharati Academy, 2015.</ref> | <ref name="ref2">Shri Bhavamishra, Bhavaprakash Nighantu, Haritakyadi Varga, Verse no. 35-38, Edited by Padmashree Pro. Krushnachandra Chunekar, Reprint Edition, Chaukhambha Bharati Academy, 2015.</ref> | ||
<ref name=" | <ref name="Wu2017">{{cite journal |last1=Wu |first1=S. |last2=Tian |first2=L. |year=2017 |title=Diverse phytochemicals and bioactivities in the ancient fruit and modern functional food pomegranate (Punica granatum) |journal=Molecules |volume=22 |issue=10 |pages=1606 |doi=10.3390/molecules22101606}}</ref> | ||
<ref name=" | <ref name="Jurenka2008">{{cite journal |last1=Jurenka |first1=J. S. |year=2008 |title=Therapeutic applications of pomegranate (Punica granatum L.): a review |journal=Alternative Medicine Review |volume=13 |issue=2 |pages=128–144}}</ref> | ||
<ref name=" | <ref name="Aviram2000">{{cite journal |last1=Aviram |first1=M. |last2=Dornfeld |first2=L. |last3=Rosenblat |first3=M. |last4=Volkova |first4=N. |last5=Kaplan |first5=M. |last6=Coleman |first6=R. |last7=Hayek |first7=T. |last8=Presser |first8=D. |last9=Fuhrman |first9=B. |year=2000 |title=Pomegranate juice consumption reduces oxidative stress, atherogenic modifications to LDL, and platelet aggregation: studies in humans and in atherosclerotic apolipoprotein E-deficient mice |journal=The American Journal of Clinical Nutrition |volume=71 |issue=5 |pages=1062–1076 |doi=10.1093/ajcn/71.5.1062}}</ref> | ||
<ref name=" | <ref name="Qnais2007">{{cite journal |last1=Qnais |first1=E. Y. |last2=Elokda |first2=A. S. |last3=Abu Ghalyun |first3=Y. Y. |last4=Abdulla |first4=F. A. |year=2007 |title=Antidiarrheal activity of the aqueous extract of Punica granatum (pomegranate) peels |journal=Pharmaceutical Biology |volume=45 |issue=9 |pages=715–720 |doi=10.1080/13880200701575304}}</ref> | ||
<ref name="Lansky2007">{{cite journal |last1=Lansky |first1=E. P. |last2=Newman |first2=R. A. |year=2007 |title=Punica granatum (pomegranate) and its potential for prevention and treatment of inflammation and cancer |journal=Journal of Ethnopharmacology |volume=109 |issue=2 |pages=177–206 |doi=10.1016/j.jep.2006.09.006}}</ref> | |||
}} | }} | ||
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