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Aconitum heterophyllum WALL. | {{#seo: | ||
|title=Charak Samhita | |||
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|keywords= Ativisha, Aconitum heterophyllum WALL., Indian Atees, Therapeutic use, herbs, researches on dravya, Charak Samhita, Dravyaguna, carakasamhitaonline, carakasamhita, caraka samhita, Ayurveda, Charak Samhita English translation, ancient Ayurveda text, Indian system of medicine, Charak, Charaka Samhita, agnivesha, atreya, gopal basisht, yogesh deole, charak samhita wikipedia edition, charak samhita new edition, charaka samhita new edition, carak samhita new edition, caraka samhita new edition, research on charak samhita, text book charak samhita, fundamental principles of ayurveda, basic concepts of ayurveda, | |||
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|image_alt=charak samhita | |||
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{{Infobox | {{Infobox | ||
| Line 6: | Line 15: | ||
|data1 = Herb database/Ativisha | |data1 = Herb database/Ativisha | ||
|label2 = Botanical name(s) | |label2 = Botanical name(s) | ||
|data2 = Aconitum heterophyllum WALL. | |data2 = [https://en.wikipedia.org/wiki/Aconitum_heterophyllum Aconitum heterophyllum WALL.] | ||
|label3 = | |label3 = Family | ||
|data3 = | |data3 = Ranunculaceae | ||
|label4 = Year of publication | |label4 = Availability | ||
| | |data4 = Available | ||
| | |label5 = Contributors | ||
| | |data5 = [[Team Dravyaguna]] | ||
| | |label6 = Year of publication | ||
| | |data6 = 2026 | ||
|label7 = Publisher | |||
|data7 = [[Charak Samhita Research, Training and Skill Development Centre]] | |||
|label8 = DOI | |||
|data8 = Awaited | |||
}} | }} | ||
== | '''[https://en.wikipedia.org/wiki/Aconitum_heterophyllum Aconitum heterophyllum WALL.]''', popularly known as '''Ativisha''' or '''Indian Atees''', is a perennial herb native to the alpine and sub-alpine regions of the Himalayas.<ref name="Wani2022" /> In [[Ayurveda]], it is highly valued as a prominent drug for managing fevers (''Jvara''), digestive ailments, and pediatric disorders, acting as an ''Ama''-pachana and Kapha-Pitta pacifying medicine.<ref name="API" /><ref name="Mathew2023" /> | ||
== English Name == | |||
Indian Atees | Indian Atees | ||
==Therapeutic Use== | == Therapeutic Use == | ||
Worms (Krimiroga), Fever (Jvara), Cough (Kasa), Vomiting (Chhardi), Amatisara<ref name="API" /> | |||
Worms (Krimiroga), Fever (Jvara), Cough (Kasa), | |||
= | |||
== Other Varieties / Other Botanical names == | |||
* Aconitum heterophyllum Wallich | * Aconitum heterophyllum Wallich | ||
* Aconitum palmatum | * Aconitum palmatum | ||
* Aconitum kashmiricum | * Aconitum kashmiricum | ||
== Identification Characters == | |||
* '''Shuklakanda''' – Root tubers are white in colour. | |||
* '''Shrungi''' – Root tubers are horn shaped.<ref name="Bhavaprakash" /> | |||
== | == Types == | ||
Based on colours of root tubers as per '''Raja Nighantu''':<ref name="RajaNighantu" /> | |||
* Rakta – Red tubers | |||
* Sweta – White tubers | |||
* Krisna – Black tubers | |||
== Synonyms in Charak Samhita == | |||
* Ativisha | |||
* Shrungi – Root tubers are horn-shaped. | |||
* Virupa | |||
* Pittadivallabha – Efficacious in Pittaja roga. | |||
* Shwetvaca | |||
* Visha | |||
* Maadri – Plant grows in Maadra desh. | |||
Visha | == Synonyms in Bhavaprakasha Nighantu == | ||
<ref name="Bhavaprakash" /> | |||
* Visha – It assimilates quickly. | |||
* Ativisha | |||
* Vishva | |||
* Shrungi – Root tubers are horn-shaped. | |||
* Prativisha | |||
* Aruna | |||
* Shuklakanda – Root tubers are white in colour. | |||
* Upavisha | |||
* Bhangura | |||
* Dhunavallabha – Root tubers are quickly infested. | |||
== Ayurvedic | == Ayurvedic Pharmacological Properties == | ||
According to classical Ayurvedic pharmacodynamics (''Rasa Panchaka''), Ativisha has the following properties:<ref name="API" /> | |||
{| class="wikitable" | {| class="wikitable sortable" style="text-align:left;" | ||
! Sr. No. !! Pharmacological Criteria !! Properties (Ayurvedic Attributes) | |||
! Sr. | |||
|- | |- | ||
| 1 || Taste ([[ | | 1 || Taste (''[[Rasa]]'') || Bitter (''Tikta''), Pungent (''Katu'') | ||
|- | |- | ||
| 2 || Potency ([[ | | 2 || Potency (''[[Veerya]]'') || Hot (''Ushna'') | ||
|- | |- | ||
| 3 || Post digestion | | 3 || Post-digestion Effect (''[[Vipaka]]'') || Pungent (''Katu'') | ||
|- | |- | ||
| 4 || Qualities ([[ | | 4 || Qualities (''[[Guna]]'') || Light (''Laghu''), Rough (''Ruksha'') | ||
|- | |- | ||
| 5 || | | 5 || Dosha Action (''[[Karma]]'') || Reduces Vata, Pitta, and Kapha | ||
|} | |} | ||
== Reference in Charak Samhita and its Actions == | |||
Ativisha is prominently documented across multiple therapeutic chapters of the ''[[Charaka Samhita]]'': | |||
{| class="wikitable sortable" style="text-align:left;" | |||
! Sr. No. !! Reference in Charak Samhita !! Activity / Formulation / Therapeutic Use | |||
{| class="wikitable" | |||
|- | |- | ||
| 1 || Cha.Sa.[[Sutra Sthana]] 4/9(3) || Lekhaniya mahakashaya (ingredient of group of herbs for treatment of emaciation) | |||
|- | |- | ||
| | | 2 || Cha.Sa.[[Sutra Sthana]] 4/9(12) || Arshoghna mahakashay (ingredient of group of herbs for treatment of piles) | ||
|Cha.Sa.[[Sutra Sthana]] | |||
| | |||
|- | |- | ||
| | | 3 || Cha.Sa.[[Sutra Sthana]] 23/19 || Santarpanajanya vikar chikitsa (management of over-nutrition disease) | ||
|Cha.Sa.[[Sutra Sthana]] | |||
|- | |- | ||
| | | 4 || Cha.Sa.[[Sutra Sthana]] 25/40 || Agrya Sangraha | ||
|Cha.Sa.[[Sutra Sthana]] | |||
| | |||
|- | |- | ||
| | | 5 || Cha.Sa.[[Vimana Sthana]] 8/139 || Madhur skanda (group of sweet drugs) | ||
|Cha.Sa.[[ | |||
| | |||
|- | |- | ||
| | | 6 || Cha.Sa.[[Vimana Sthana]] 8/143 || Tiktaskandha (group of bitter drugs) | ||
|Cha.Sa.[[Vimana Sthana]] | |||
| | |||
|- | |- | ||
| | | 7 || Cha.Sa.[[Chikitsa Sthana]] 3/204 || As an ingredient of Vatsakadi kashaya | ||
|Cha.Sa.[[ | |||
| | |||
|- | |- | ||
| | | 8 || Cha.Sa.[[Chikitsa Sthana]] 3/219 || As an ingredient of Pippalyadi Ghrita | ||
|Cha.Sa.[[Chikitsa Sthana]] | |||
|As an ingredient of | |||
|- | |- | ||
| | | 9 || Cha.Sa.[[Chikitsa Sthana]] 6/38 || Trikantakadhya Tail/Ghrit in Vata-kaphaj prameha | ||
|Cha.Sa.[[Chikitsa Sthana]] | |||
| | |||
|- | |- | ||
| | | 10 || Cha.Sa.[[Chikitsa Sthana]] 6/42 || Ingredient in Madhvasava | ||
|Cha.Sa.[[Chikitsa Sthana]] 6/ | |||
| | |||
|- | |- | ||
| | | 11 || Cha.Sa.[[Chikitsa Sthana]] 11/16 || As a diet and drinks in treatment of Kshatakshina | ||
|Cha.Sa.[[Chikitsa Sthana]] | |||
| | |||
|- | |- | ||
| | | 12 || Cha.Sa.[[Chikitsa Sthana]] 12/44 || Ingredient in Kshar Gudika | ||
|Cha.Sa.[[Chikitsa Sthana]] | |||
| | |||
|- | |- | ||
| | | 13 || Cha.Sa.[[Chikitsa Sthana]] 13/159 || In formulation of Pippalyadi lavana | ||
|Cha.Sa.[[Chikitsa Sthana]] | |||
| | |||
|- | |- | ||
| | | 14 || Cha.Sa.[[Chikitsa Sthana]] 14/187 || Used for raktastambhana | ||
|Cha.Sa.[[Chikitsa Sthana]] | |||
| | |||
|- | |- | ||
| | | 15 || Cha.Sa.[[Chikitsa Sthana]] 14/230 || As an ingredient of Hriberadi ghrita | ||
|Cha.Sa.[[Chikitsa Sthana]] | |||
| | |||
|- | |- | ||
| | | 16 || Cha.Sa.[[Chikitsa Sthana]] 14/236 || As an ingredient of Sunishanak changeri ghrita | ||
|Cha.Sa.[[Chikitsa Sthana]] | |||
|As an | |||
|- | |- | ||
| | | 17 || Cha.Sa.[[Chikitsa Sthana]] 15/98 || Kalka of this drug is used for Aampachan (with usnodaka) | ||
|Cha.Sa.[[Chikitsa Sthana]] | |||
| | |||
|- | |- | ||
| | | 18 || Cha.Sa.[[Chikitsa Sthana]] 15/99 || Churna of this drug with combination of vaca, musta, etc. is given in aam and shoola yukta mala | ||
|Cha.Sa.[[Chikitsa Sthana]] | |||
15/ | |||
| | |||
|- | |- | ||
| | | 19 || Cha.Sa.[[Chikitsa Sthana]] 15/101 || Churna with hingu, abhaya, vaca etc. used in Sama and Vatakapha adhika grahani with kostha shola | ||
|Cha.Sa.[[Chikitsa Sthana]] | |||
|Churna | |||
|- | |- | ||
| | | 20 || Cha.Sa.[[Chikitsa Sthana]] 15/105 || Used in Kaphapittaja grahani | ||
|Cha.Sa.[[Chikitsa Sthana]] | |||
| | |||
|- | |- | ||
| | | 21 || Cha.Sa.[[Chikitsa Sthana]] 15/129 || As an ingredient of Nagaradhya churna | ||
|Cha.Sa.[[Chikitsa Sthana]] | |||
| | |||
|- | |- | ||
| | | 22 || Cha.Sa.[[Chikitsa Sthana]] 15/134, 15/138 || As an ingredient of Kiratadhya churna (Pittaja Grahani chikitsa) | ||
|Cha.Sa.[[Chikitsa Sthana]] | |||
|As an | |||
|- | |- | ||
| | | 23 || Cha.Sa.[[Chikitsa Sthana]] 15/165 || As an ingredient of Madhvarista | ||
|Cha.Sa.[[Chikitsa Sthana]] | |||
15/ | |||
|As an | |||
|- | |- | ||
| | | 24 || Cha.Sa.[[Chikitsa Sthana]] 15/173 || As an ingredient of Pipallimuladhya Kshara | ||
|Cha.Sa.[[Chikitsa Sthana]] | |||
|As an | |||
|- | |- | ||
| | | 25 || Cha.Sa.[[Chikitsa Sthana]] 15/186 || Used in preparation of Chaturtha Kshara | ||
|Cha.Sa.[[Chikitsa Sthana]] | |||
| | |||
|- | |- | ||
| | | 26 || Cha.Sa.[[Chikitsa Sthana]] 16/61 || As an ingredient of Vishaladi Phanta | ||
|Cha.Sa.[[Chikitsa Sthana]] | |||
| | |||
|- | |- | ||
| | | 27 || Cha.Sa.[[Chikitsa Sthana]] 18/115 || As an ingredient of Nagaradi yoga | ||
|Cha.Sa.[[Chikitsa Sthana]] | |||
|As an ingredient of | |||
|- | |- | ||
| | | 28 || Cha.Sa.[[Chikitsa Sthana]] 19/22 || As an ama pachak dravya | ||
|Cha.Sa.[[Chikitsa Sthana]] | |||
|As an | |||
|- | |- | ||
| | | 29 || Cha.Sa.[[Chikitsa Sthana]] 19/51 || As an ingredient of Ativishadi yoga | ||
|Cha.Sa.[[Chikitsa Sthana]] | |||
|As | |||
|- | |- | ||
| | | 30 || Cha.Sa.[[Chikitsa Sthana]] 19/105 || As a kwatha dravya | ||
|Cha.Sa.[[Chikitsa Sthana]] | |||
|As | |||
|- | |- | ||
| | | 31 || Cha.Sa.[[Chikitsa Sthana]] 19/108 || As an ingredient of Rasanjanadi yoga | ||
|Cha.Sa.[[Chikitsa Sthana]] | |||
|As | |||
|- | |- | ||
| | | 32 || Cha.Sa.[[Chikitsa Sthana]] 26/21 || As an ingredient of Vachadi churna | ||
|Cha.Sa.[[Chikitsa Sthana]] | |||
|As an ingredient of | |||
|- | |- | ||
| | | 33 || Cha.Sa.[[Chikitsa Sthana]] 26/97 || As an ingredient of Katphaladi kashaya | ||
|Cha.Sa.[[Chikitsa Sthana]] | |||
|As an ingredient of | |||
|- | |- | ||
| | | 34 || Cha.Sa.[[Chikitsa Sthana]] 26/101 || Used in Hrudshoola | ||
|Cha.Sa.[[Chikitsa Sthana]] | |||
| | |||
|- | |- | ||
| | | 35 || Cha.Sa.[[Chikitsa Sthana]] 26/201 || As an ingredient of Katukadi kashaya | ||
|Cha.Sa.[[Chikitsa Sthana]] | |||
| | |||
|- | |- | ||
| | | 36 || Cha.Sa.[[Chikitsa Sthana]] 27/35 || As an ingredient of Murvadi Choorna | ||
|Cha.Sa.[[Chikitsa Sthana]] | |||
|As an ingredient | |||
|- | |- | ||
| | | 37 || Cha.Sa.[[Chikitsa Sthana]] 27/36 || As an ingredient of Swarnakshiradi Choorna | ||
|Cha.Sa.[[Chikitsa Sthana]] | |||
|As an | |||
|- | |- | ||
| | | 38 || Cha.Sa.[[Chikitsa Sthana]] 28/151 || As an ingredient of Bala taila | ||
|Cha.Sa.[[Chikitsa Sthana]] | |||
|As an ingredient | |||
|- | |- | ||
| | | 39 || Cha.Sa.[[Chikitsa Sthana]] 28/168 || As an ingredient of Mulakadhya taila | ||
| | |||
|Cha.Sa.[[Chikitsa Sthana]] | |||
|As an ingredient of Mulakadhya taila | |||
|} | |} | ||
==Purification== | == Purification (Shodhana) == | ||
Ativisha tuberous roots are cut into pieces and kept in Gomutra kvatha for 3 hours and then dried in sunlight.<ref name="Shodhana" /> | |||
Ativisha tuberous roots | |||
== | == Dose == | ||
* '''Powder (''Churna''):''' 0.6 – 2 g daily.<ref name="API" /> | |||
== Important Formulations == | |||
As per A.P.I.<ref name="API" /> | |||
* Mahavisagarbha Taila | * Mahavisagarbha Taila | ||
* Rodhrasava | * Rodhrasava | ||
| Line 260: | Line 196: | ||
* Bala Chaturbhadra Churna | * Bala Chaturbhadra Churna | ||
== Current Availability == | |||
== | Available | ||
* '''In India:''' Jammu & Kashmir, Himachal Pradesh, Uttarakhand | |||
* '''Out of India:''' Northern Pakistan, Nepal | |||
Conservation status: the species is reported as critically endangered because of over-harvesting.<ref name="Wani2022" /> | |||
== Major Phytoconstituents == | |||
The pharmacological properties of ''Aconitum heterophyllum'' are primarily attributed to its diterpenoid alkaloids, which are concentrated in the root tubers:<ref name="Mathew2023" /> | |||
* '''Diterpenoid Alkaloids:''' Atisine,<ref name="Malhotra2014" /><ref name="Jowett1896" /> atidine,<ref name="Jowett1896" /> heteratisine and benzoylheteratisine, and aconitine (used as the HPLC marker compound for standardisation).<ref name="Prasad2014" /> Heterophylline, heterophylloidine, fischimine and aconine derivatives <sup>[citation needed]</sup> | |||
* '''Lactones & Flavonoids:''' Bitter principles and phenolic compounds contributing to digestive and anti-inflammatory actions | |||
== Therapeutic Efficacy & Modern Scientific Research == | |||
Modern pharmacological evaluations and experimental research support some of the traditional therapeutic indications of ''Aconitum heterophyllum'': | |||
=== 1. Anti-diarrheal Action (''Atisara'') === | |||
* '''Traditional Use:''' Widely used for ''Amatisara'' (diarrhea associated with toxic metabolic wastes) and pediatric gastrointestinal disturbances.<ref name="API" /><ref name="Mathew2023" /> | |||
* '''Mechanism & Scientific Evidence:''' In rat models, an ethanol extract of the roots showed anti-diarrheal activity in castor oil-induced diarrhea and fecal excretion tests. Further tests showed reduced small intestinal transit, reduced intestinal fluid accumulation and inhibition of PGE2-induced enteropooling, indicating antisecretory and antimotility effects that appear to be mediated through the nitric oxide pathway.<ref name="Prasad2014" /> | |||
=== 2. Antipyretic and Anti-inflammatory Properties (''Jvara'') === | |||
* '''Traditional Use:''' Root tubers are commonly used in pediatric medicine for fever management and have been used as an antipyretic and anti-inflammatory agent.<ref name="Mathew2023" /> | |||
* '''Mechanism & Scientific Evidence:''' A network pharmacology and docking study, validated in LPS-stimulated RAW264.7 macrophages, found that a root extract reduced nitric oxide release and iNOS expression, and suppressed EGFR/AKT1 and EGFR/JAK2/STAT3 signalling.<ref name="Meng2025" /> These findings are preclinical (in silico and in vitro); direct experimental evidence for the antipyretic effect was not identified in the sources reviewed. | |||
=== 3. Antimicrobial Activity === | |||
* '''Traditional Use:''' Used to combat infections and normalize bodily humors.<ref name="Mathew2023" /> | |||
* '''Mechanism & Scientific Evidence:''' An aconitine-standardised root extract (0.0833% w/w aconitine) showed antibacterial activity against microbes implicated in diarrhea.<ref name="Prasad2014" /> | |||
== Summary of Therapeutic Profile == | |||
{| class="wikitable sortable" style="text-align: left;" | |||
|+ Therapeutic Applications of ''Aconitum heterophyllum'' | |||
! Indication | |||
! Active Biomolecules | |||
! Primary Pharmacological Action | |||
|- | |||
| '''Diarrhea & Dysentery (''Atisara'')''' | |||
| Diterpenoid alkaloids (aconitine used as marker) | |||
| Anti-motility, anti-secretory, antibacterial<ref name="Prasad2014" /> | |||
|- | |||
| '''Fever & Inflammation (''Jvara'')''' | |||
| Diterpenoid alkaloids | |||
| Traditional antipyretic use;<ref name="Mathew2023" /> inhibition of NO release and EGFR/JAK2/STAT3 signalling in vitro<ref name="Meng2025" /> | |||
|- | |||
| '''Microbial Infections''' | |||
| Aconitine-standardised extract | |||
| Antibacterial activity in vitro<ref name="Prasad2014" /> | |||
|} | |||
== | == Safety, Toxicity, and Dosage == | ||
* '''Precautions:''' Raw or unpurified roots contain potent aconite-type alkaloids that can be toxic; hence, strict adherence to classical purification (''Shodhana'') processes is mandatory prior to therapeutic usage.<ref name="Shodhana" /> | |||
* '''Standard Therapeutic Dosage:''' | |||
** ''Root Powder (Churna):'' 0.6–2 g daily.<ref name="API" /> | |||
== References == | |||
{{Reflist|refs= | |||
<ref name="API">Anonymous. The Ayurvedic Pharmacopoeia of India. Part I, Vol. I. New Delhi: Government of India, Ministry of Health and Family Welfare; 1986. p. 14.</ref> | |||
<ref name="RajaNighantu">Tripathi I, editor. Raj Nighantu of Pandit Narahari, Pippalyadi Varga, verse 136. Varanasi: Chaukhambha Krishnadas Academy. </ref> | |||
<ref name="Bhavaprakash">Bhavamishra. Bhavaprakash Nighantu, Haritakyadi Varga, verses 186–187. Chunekar KC, editor. Reprint ed. Varanasi: Chaukhambha Bharati Academy; 2015.</ref> | |||
<ref name="Shodhana">Tripathi I, editor. Raj Nighantu of Pandit Narahari, Pippalyadi Varga, verse 137. Varanasi: Chaukhambha Krishnadas Academy.</ref> | |||
<ref name="Prasad2014">Prasad SK, Jain D, Patel DK, Sahu AN, Hemalatha S. Antisecretory and antimotility activity of ''Aconitum heterophyllum'' and its significance in treatment of diarrhea. ''Indian J Pharmacol''. 2014;46(1):82–87. [https://pmc.ncbi.nlm.nih.gov/articles/PMC3912813/ PMC3912813]</ref> | |||
<ref name="Mathew2023">Mathew A, Chandrashekar KS, Kishore A, Pai V, Aswatha Ram HN, Pemmereddy R. Therapeutic potential of ''Aconitum heterophyllum'': a review on phyto-pharmacological properties. ''Res J Pharm Technol''. 2023;16(1):470–476.</ref> | |||
<ref name="Meng2025">Meng X, Xu X, Shi L, Liu Y, Deng J, Huang X. Network pharmacology combining molecular docking to unveil the anti-inflammatory mechanism of ''Aconitum heterophyllum''. ''Food Nutr Health''. 2025;2:7. [https://doi.org/10.1007/s44403-025-00016-1 doi:10.1007/s44403-025-00016-1]</ref> | |||
<ref name="Wani2022">Wani TA, Kaloo ZA, Dangroo NA. ''Aconitum heterophyllum'' Wall. ex Royle: a critically endangered medicinal herb with rich potential for use in medicine. ''J Integr Med''. 2022;20(2):104–113. [https://doi.org/10.1016/j.joim.2021.12.004 doi:10.1016/j.joim.2021.12.004]</ref> | |||
<ref name="Malhotra2014">Malhotra N, Kumar V, Sood H, Singh TR, Chauhan RS. Multiple genes of mevalonate and non-mevalonate pathways contribute to high aconites content in an endangered medicinal herb, ''Aconitum heterophyllum'' Wall. ''Phytochemistry''. 2014;108:26–34. [https://doi.org/10.1016/j.phytochem.2014.08.025 doi:10.1016/j.phytochem.2014.08.025]</ref> | |||
<ref name="Jowett1896">Jowett HAD. Contributions to our knowledge of the aconite alkaloids. Part XIII. On atisine, the alkaloid of ''Aconitum heterophyllum''. ''J Chem Soc Trans''. 1896;69:1518–1526. [https://doi.org/10.1039/CT8966901518 doi:10.1039/CT8966901518]</ref> | |||
}} | |||
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