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[https://en.wikipedia.org/wiki/Trachyspermum_ammi Carum copticum Benth. & Hook]
{{#seo:
{{#seo:
|title=Charak Samhita - Herb Database
|title=Charak Samhita
|titlemode=append
|titlemode=append
|keywords=Dipyaka, Carum copticum, Trachyspermum ammi, Ajowan, Ajwain, Charak Samhita, Dravyaguna, Ayurvedic pharmacopoeia
|keywords= *Dipyaka, Carum copticum Benth. & Hook, Ajowan* Therapeutic use, herbs, researches on dravya, Charak Samhita, Dravyaguna, carakasamhitaonline, carakasamhita, caraka samhita, Ayurveda, Charak Samhita English translation, ancient Ayurveda text, Indian system of medicine, Ayurveda, Charak, Charaka Samhita, agnivesha, atreya, gopal basisht, yogesh deole, charak samhita wikipedia edition, charak samhita new edition, charaka samhita new edition, carak samhita new edition, caraka samhita new edition, research on charak samhita, text book charak samhita, fundamental principles of ayurveda, basic concepts of ayurveda,
|description=Monograph on Dipyaka (Carum copticum Benth. & Hook): comprehensive botanical profile, classical Ayurvedic pharmacodynamics, and therapeutic uses.
|description= Dipyaka (Trachyspermum ammi (L.) Sprague / Carum copticum) is traditionally classified as a deepana (digestive stimulant), pachana, and anulomaka herb, widely utilized in Ayurveda for managing gastrointestinal disorders, abdominal colic, indigestion, and respiratory ailments.
|image=http://www.carakasamhitaonline.com/resources/assets/ogimgs.jpg
|image=http://www.carakasamhitaonline.com/resources/assets/ogimgs.jpg
|image_alt=Dipyaka - Carum copticum
|image_alt=charak samhita
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|type=article
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{{Infobox
{{Infobox
|title =  
|title = Dipyaka
|label1 = Section/Chapter
|label1 = Section/Chapter
|data1 = Herb database/Dipyaka
|data1 = Herb database/Dipyaka
|label2 = Botanical name(s)
|label2 = Botanical name(s)
|data2 = Carum copticum Benth. & Hook
|data2 = [https://en.wikipedia.org/wiki/Trachyspermum_ammi Carum copticum Benth. & Hook]
|label3 = Family
|label3 = Family
|data3 = Umbeliferae
|data3 = Umbelliferae
|label4 = Availability
|label4 = Availability
|data4 = Available
|data4 = Available
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}}
}}


'''Dipyaka''' (Latin: ''Carum copticum'' Benth. & Hook.; family: Umbelliferae) is an annual herbaceous plant widely cultivated for its aromatic fruits. In [[Ayurveda]], it is highly valued as a carminative, digestive stimulant, and Kapha-Vata pacifying medicine.<ref name="API">{{cite book |title=The Ayurvedic Pharmacopoeia of India |year=1986 |publisher=Department of Ayush, Ministry of Health and Family Welfare, Govt. of India |volume=1 |pages=02 |edition=Part I}}</ref>
'''[https://en.wikipedia.org/wiki/Trachyspermum_ammi Carum copticum Benth. & Hook.]''', commonly known as '''Dipyaka''' or '''Ajowan''', is an annual herbaceous plant widely cultivated for its aromatic fruits. In [[Ayurveda]], it is highly valued as a carminative, digestive stimulant, and Kapha-Vata pacifying medicine.<ref name="API" /> ''Trachyspermum ammi'' (L.) Sprague is regarded as a synonym of ''Carum copticum''.<ref name="Boskabady2014" />


== English Name ==
== English Name ==
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* ''Brahmakusha''
* ''Brahmakusha''
* ''Kaaravi''
* ''Kaaravi''
* ''Lochamastaka''<ref name="Bhavaprakash">{{cite book |last=Chunekar |first=Krushnachandra |title=Bhavaprakash Nighantu |year=2020 |publisher=Chaukhambha Bharati Academy |pages=Haritakyadi varga, verse no.- 77 |edition=Reprint}}</ref>
* ''Lochamastaka''<ref name="Bhavaprakash" />


== Ayurvedic Pharmacological Properties ==
== Ayurvedic Pharmacological Properties ==
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* '''Powder (''Churna''):''' 1 – 3 g daily.<ref name="API" />
* '''Powder (''Churna''):''' 1 – 3 g daily.<ref name="API" />


== Important Formulation ==
== Important Formulations ==
As per A.P.I.<ref name="API" />
As per A.P.I.<ref name="API" />
* ''Ajamodarka''
* ''Ajamodarka''
* ''Ajmodadi churna''
* ''Ajmodadi churna''
== Current Availability ==
Available


== Major Phytoconstituents ==
== Major Phytoconstituents ==
The pharmacological efficacy of ''Trachyspermum ammi'' is predominantly attributed to its essential oil content, which ranges from 2% to 5%. The primary active constituent is '''thymol''' (accounting for 35% to 60% of the oil), accompanied by p-cymene, γ-terpinene, α-pinene, β-pinene, and carvacrol.
The pharmacological activity of ''Trachyspermum ammi'' (''Carum copticum'') is mainly attributed to its essential oil. The oil composition varies with geographical origin: thymol is the main component of oil from south Indian plants (reported up to 97.9%), whereas carvacrol, &gamma;-terpinene and ''p''-cymene are the main components of oil from other regions.<ref name="Boskabady2014" />


== Therapeutic Efficacy & Modern Scientific Research ==
== Therapeutic Efficacy & Modern Scientific Research ==
Modern pharmacological evaluations and clinical studies validate many of the traditional claims associated with *Trachyspermum ammi*. Its core therapeutic domains include:
Modern pharmacological studies support several of the traditional uses of ''Trachyspermum ammi'' (''Carum copticum''):


=== 1. Gastrointestinal and Carminative Activity (''Deepana'' & ''Pachana'') ===
=== 1. Gastrointestinal and Antispasmodic Activity (''Deepana'' & ''Pachana'') ===
* '''Traditional Use:''' Used for *Gulma* (abdominal lump), *Adhmana* (abdominal distention), *Aruchi* (anorexia), and *Sula* (colic pain).
* '''Traditional Use:''' Used for ''Gulma'' (abdominal lump), ''Adhmana'' (abdominal distention), ''Aruchi'' (anorexia) and ''Sula'' (colic pain).<ref name="API" />
* '''Scientific Evidence:''' Animal and in vitro studies demonstrate that the extract and essential oil of *T. ammi* exhibit significant anti-spasmodic (anticholinergic-like) and smooth-muscle relaxing properties. The carminative action is primarily mediated by thymol, which stimulates the secretion of gastric juices, enhances metabolic activity, and relieves flatulence and intestinal colic.
* '''Scientific Evidence:''' The aqueous-methanolic seed extract inhibited K<sup>+</sup>-induced contractions in isolated rabbit jejunum and shifted Ca<sup>2+</sup> dose-response curves to the right, similar to verapamil, indicating a calcium channel blocking (antispasmodic) effect.<ref name="Gilani2005" />
* '''Reference:''' *Tharakan, S. T., et al.* "Evaluation of spasmolytic and bronchodilator activities of Trachyspermum ammi." *Journal of Ethnopharmacology*.


=== 2. Antimicrobial and Antifungal Efficacy (''Krumiroga'') ===
=== 2. Antimicrobial Efficacy (''Krumiroga'') ===
* '''Traditional Use:''' Employed in *Krumi roga* (parasitic and microbial infections).
* '''Traditional Use:''' Employed in ''Krumi roga'' (worms / microbial infections).<ref name="API" />
* '''Scientific Evidence:''' *T. ammi* essential oil and isolated thymol exhibit broad-spectrum antimicrobial activity against various pathogenic bacteria (including *Staphylococcus aureus*, *Escherichia coli*, *Pseudomonas aeruginosa*) and fungi (such as *Candida albicans*). The high phenolic content disrupts microbial cell membranes, causing leakage of intracellular constituents.
* '''Scientific Evidence:''' The essential oil of ''Carum copticum'' and its main compounds have been reported to have antibacterial and antifungal activity, assessed by MIC and MBC methods.<ref name="Kazemi2015" />
* '''Reference:''' *Khosravi, A. R., et al.* "In vitro antifungal activity of Trachyspermum ammi essential oil against dermatophytes." *Mycoses*.


=== 3. Respiratory Support (''Hikka'' & Bronchodilation) ===
=== 3. Respiratory Support (''Swasa'' & Bronchodilation) ===
* '''Traditional Use:''' Used in respiratory distress, asthma (*Swasa*), and cough.
* '''Traditional Use:''' Used in asthma and dyspnea (''Swasa'') and cough; the plant is described in traditional medicine as anti-asthmatic and anti-dyspneic.<ref name="Boskabady2014" />
* '''Scientific Evidence:''' Pharmacological studies confirm that the bronchodilator activity of *T. ammi* is comparable to standard reference drugs (like theophylline/atropine). The relaxation of tracheal chains by thymol and carvacrol facilitates easier airflow, validating its traditional use in obstructive airway diseases.
* '''Scientific Evidence:''' The seed extract inhibited carbachol- and K<sup>+</sup>-induced contractions in isolated guinea-pig trachea and shifted the carbachol and histamine dose-response curves to the right, suggesting a non-specific bronchodilator effect possibly mediated through calcium channel blockade.<ref name="Gilani2005" /> Bronchodilator effects of ''C. copticum'' have also been reviewed.<ref name="Boskabady2014" />
* '''Reference:''' *Boskabady, M. H., et al.* "Bronchodilator and anticough effects of Trachyspermum ammi." *Research Reports*.


=== 4. Antioxidant and Anti-inflammatory Properties ===
=== 4. Antioxidant and Anti-inflammatory Properties ===
* '''Scientific Evidence:''' *T. ammi* seeds possess significant free-radical scavenging abilities due to their high concentration of phenolic compounds. In vivo anti-inflammatory models show that extracts can reduce acute and chronic inflammation, partly by inhibiting inflammatory pathways and prostaglandin synthesis.
* '''Scientific Evidence:''' The essential oil of ''Carum copticum'' showed antioxidant and anti-inflammatory properties in laboratory evaluation.<ref name="Kazemi2015" />
* '''Reference:''' *Javed, I., et al.* "Antioxidant and anti-inflammatory activities of Trachyspermum ammi extracts." *Phytotherapy Research*.
 
=== 5. Hepatoprotective and Antihypertensive Activity ===
* '''Scientific Evidence:''' In rats, pretreatment with the seed extract (500 mg/kg orally) prevented the rise in serum ALP and aminotransferases induced by paracetamol and carbon tetrachloride, and the extract caused a dose-dependent fall in arterial blood pressure in anaesthetized rats (3&ndash;100 mg/kg).<ref name="Gilani2005" />


== Current Availability ==
== Summary of Therapeutic Profile ==
Available
{| class="wikitable sortable" style="text-align: left;"
|+ Therapeutic Applications of ''Trachyspermum ammi''
! Indication
! Active Biomolecules
! Primary Pharmacological Action
|-
| '''Gastrointestinal Colic / Flatulence'''
| Seed extract (calcium antagonist constituents)
| Antispasmodic (calcium channel blockade)<ref name="Gilani2005" />
|-
| '''Microbial / Fungal Infections'''
| Essential oil
| Antibacterial, antifungal<ref name="Kazemi2015" />
|-
| '''Respiratory Disorders / Asthma'''
| Seed extract
| Bronchodilation, tracheal smooth muscle relaxation<ref name="Gilani2005" />
|-
| '''Inflammation / Oxidative Stress'''
| Essential oil
| Antioxidant, anti-inflammatory<ref name="Kazemi2015" />
|}


== Current Researches ==
== Safety, Toxicity, and Dosage ==
* Under development.
* '''Precautions:''' Due to the hot potency (''Ushna veerya'') and sharp qualities (''Tikshna guna''), it should be used cautiously in individuals with high Pitta aggravation or severe gastritis. This is a classical rationale rather than a clinical finding.
* '''Standard Therapeutic Dosage:'''
** ''Fruit Powder (Churna):'' 1 – 3 g daily.<ref name="API" />


== References ==
== References ==
{{Reflist|refs=
{{Reflist|refs=
<ref name="API">{{cite book |title=The Ayurvedic Pharmacopoeia of India |year=1986 |publisher=Department of Ayush, Ministry of Health and Family Welfare, Govt. of India |volume=1 |pages=02 |edition=Part I}}</ref>
<ref name="API">{{cite book |title=The Ayurvedic Pharmacopoeia of India |year=1986 |publisher=Department of Ayush, Ministry of Health and Family Welfare, Govt. of India |location=New Delhi |edition=Part I |volume=I |pages=02}}</ref> <!-- verify volume and page -->
<ref name="Bhavaprakash">{{cite book |last=Chunekar |first=Krushnachandra |title=Bhavaprakash Nighantu |year=2020 |publisher=Chaukhambha Bharati Academy |pages=Haritakyadi varga, verse no.- 77 |edition=Reprint}}</ref>
<ref name="Bhavaprakash">{{cite book |last=Bhavamishra |first=Shri |title=Bhavaprakash Nighantu |others=Edited by Padmashree Prof. Krushnachandra Chunekar |edition=Reprint |publisher=Chaukhambha Bharati Academy |year=2020 |pages=Haritakyadi Varga, verse 77}}</ref>
<ref name="Boskabady2014">{{cite journal |last1=Boskabady |first1=M. H. |last2=Alitaneh |first2=S. |last3=Alavinezhad |first3=A. |year=2014 |title=Carum copticum L.: a herbal medicine with various pharmacological effects |journal=BioMed Research International |volume=2014 |pages=569087 |doi=10.1155/2014/569087 |url=https://pmc.ncbi.nlm.nih.gov/articles/PMC4096002}}</ref>
<ref name="Gilani2005">{{cite journal |last1=Gilani |first1=A. H. |last2=Jabeen |first2=Q. |last3=Ghayur |first3=M. N. |last4=Janbaz |first4=K. H. |last5=Akhtar |first5=M. S. |year=2005 |title=Studies on the antihypertensive, antispasmodic, bronchodilator and hepatoprotective activities of the Carum copticum seed extract |journal=Journal of Ethnopharmacology |volume=98 |issue=1–2 |pages=127–135 |doi=10.1016/j.jep.2005.01.017 |pmid=15763373 |url=https://pubmed.ncbi.nlm.nih.gov/15763373/}}</ref>
<ref name="Kazemi2015">{{cite journal |last=Kazemi |first=M. |year=2015 |title=Phenolic profile, antimicrobial and anti-inflammatory activity of Carum copticum L. essential oil |journal=Bulgarian Chemical Communications |volume=47 |issue=1 |pages=149–155 |url=https://hero.epa.gov/hero/index.cfm/reference/details/reference_id/3440018}}</ref>
}}
}}


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